Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 2924
TargetEpidermal growth factor receptor [696-1022,L858R](Human)
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  1.10nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [696-1022,L858R](Human)
Harvard Medical School

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  2.40nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [696-1022,T790M](Human)
Harvard Medical School

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  4.60nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  5.30nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  10.9nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  18.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [696-1022,T790M](Human)
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  27.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  35.3nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)