Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50038083
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233761((R)-tert-butyl 1-oxo-1-((3-(1-phenylcyclopropyl)-3...)
Affinity DataIC50: 63nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233780((R)-tert-butyl 1-((3-benzyl-3H-imidazo[4,5-b]pyrid...)
Affinity DataIC50: 80nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233795((R)-tert-butyl 1-oxo-1-((3-(2,2,2-trifluoroethyl)-...)
Affinity DataIC50: 81nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233771((R)-tert-butyl 1-((3-neopentyl-3H-imidazo[4,5-b]py...)
Affinity DataIC50: 83nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233757((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 86nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233763((R)-tert-butyl 3-(2-chloro-5-fluorophenyl)-1-oxo-1...)
Affinity DataIC50: 102nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233790((R)-tert-butyl 1-oxo-1-((3-(2,2,3,3,3-pentafluorop...)
Affinity DataIC50: 123nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233760((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 129nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233792((R)-tert-butyl 3-(2-chlorophenyl)-1-oxo-1-((3-(1-p...)
Affinity DataIC50: 132nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233775((R)-tert-butyl 3-(2-chloro-6-fluorophenyl)-1-oxo-1...)
Affinity DataIC50: 147nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233762((R)-tert-butyl 1-oxo-1-((3-(1-phenylcyclopropyl)-3...)
Affinity DataIC50: 148nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233769((R)-tert-butyl 3-(2,5-difluorophenyl)-1-oxo-1-((3-...)
Affinity DataIC50: 148nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233786((R)-tert-butyl 3-(2-fluoro-6-(trifluoromethyl)phen...)
Affinity DataIC50: 153nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233765((R)-tert-butyl 3-(3-fluoro-2-(trifluoromethyl)phen...)
Affinity DataIC50: 158nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233782((R)-tert-butyl 3-(2-fluorophenyl)-1-oxo-1-((3-(1-p...)
Affinity DataIC50: 158nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233776((R)-tert-butyl 3-(2,6-difluorophenyl)-1-oxo-1-((3-...)
Affinity DataIC50: 171nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233785((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 181nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233773((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 182nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233791((R)-tert-butyl 1-((3-tert-butyl-3H-imidazo[4,5-b]p...)
Affinity DataIC50: 185nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233783((R)-tert-butyl 1-oxo-1-((3-(1-phenylcyclopropyl)-3...)
Affinity DataIC50: 186nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233774(tert-butyl (R)-1-oxo-1-((3-((R)-1-phenylethyl)-3H-...)
Affinity DataIC50: 191nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233770((R)-tert-butyl 3-(3-chlorophenyl)-1-oxo-1-((3-(1-p...)
Affinity DataIC50: 221nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233760((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 230nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233781((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 232nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233764((R)-tert-butyl 1-((3-(cyclopropylmethyl)-3H-imidaz...)
Affinity DataIC50: 243nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233778(tert-butyl (R)-1-oxo-1-((3-((S)-1-phenylethyl)-3H-...)
Affinity DataIC50: 255nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233772(N-[(R)-1-[(3-benzyl-3H-imidazo[4,5-b]pyridin-2-ylm...)
Affinity DataIC50: 261nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233777((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 261nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233780((R)-tert-butyl 1-((3-benzyl-3H-imidazo[4,5-b]pyrid...)
Affinity DataIC50: 270nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233766((R)-tert-butyl 3-(2,3-difluorophenyl)-1-oxo-1-((3-...)
Affinity DataIC50: 275nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233763((R)-tert-butyl 3-(2-chloro-5-fluorophenyl)-1-oxo-1...)
Affinity DataIC50: 295nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233784((R)-N-(3-(2-chlorophenyl)-1-oxo-1-((3-(1-phenylcyc...)
Affinity DataIC50: 329nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233757((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 361nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233781((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 366nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233767((R)-tert-butyl 1-oxo-3-phenyl-1-((3-(1-phenylcyclo...)
Affinity DataIC50: 394nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233773((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 446nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233761((R)-tert-butyl 1-oxo-1-((3-(1-phenylcyclopropyl)-3...)
Affinity DataIC50: 446nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233788((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 476nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233792((R)-tert-butyl 3-(2-chlorophenyl)-1-oxo-1-((3-(1-p...)
Affinity DataIC50: 500nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233787((R)-N-(3-(2,6-difluorophenyl)-1-oxo-1-((3-(1-pheny...)
Affinity DataIC50: 540nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233789((R)-N-(1-((3-benzyl-3H-imidazo[4,5-b]pyridin-2-yl)...)
Affinity DataIC50: 552nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233776((R)-tert-butyl 3-(2,6-difluorophenyl)-1-oxo-1-((3-...)
Affinity DataIC50: 685nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233779((R)-tert-butyl 3-(4-fluoro-2-(trifluoromethyl)phen...)
Affinity DataIC50: 744nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233783((R)-tert-butyl 1-oxo-1-((3-(1-phenylcyclopropyl)-3...)
Affinity DataIC50: 793nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233765((R)-tert-butyl 3-(3-fluoro-2-(trifluoromethyl)phen...)
Affinity DataIC50: 806nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233765((R)-tert-butyl 3-(3-fluoro-2-(trifluoromethyl)phen...)
Affinity DataIC50: 810nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233783((R)-tert-butyl 1-oxo-1-((3-(1-phenylcyclopropyl)-3...)
Affinity DataIC50: 820nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233785((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 825nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233758(tert-butyl (R)-1-((3-(1-cyclopropylethyl)-3H-imida...)
Affinity DataIC50: 860nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233782((R)-tert-butyl 3-(2-fluorophenyl)-1-oxo-1-((3-(1-p...)
Affinity DataIC50: 880nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
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