Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 2567
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKi:  0.0480nM ΔG°:  -58.3kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22103(7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H...)
Affinity DataKi:  0.229nM ΔG°:  -54.5kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22112(7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl...)
Affinity DataKi:  0.450nM ΔG°:  -52.8kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22103(7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H...)
Affinity DataKi:  0.665nM ΔG°:  -51.9kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Industrial Research

LigandPNGBDBM22110([1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methy...)
Affinity DataKi:  0.840nM ΔG°:  -51.3kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  1.10nM ΔG°:  -50.6kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Industrial Research

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Industrial Research

LigandPNGBDBM22112(7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22105(7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22105(7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  6.30nM ΔG°:  -46.3kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  12.9nM ΔG°:  -44.6kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  16nM ΔG°:  -44.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetAdenosylhomocysteine nucleosidase(Streptococcus pneumoniae)
Industrial Research

LigandPNGBDBM22113(DADMe-ImmA-Me | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2...)
Affinity DataKi:  24nM ΔG°:  -43.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetAdenosylhomocysteine nucleosidase(Streptococcus pneumoniae)
Industrial Research

LigandPNGBDBM22112(7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl...)
Affinity DataKi:  84nM ΔG°:  -40.0kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetS-methyl-5'-thioadenosine phosphorylase(Human)
Industrial Research

LigandPNGBDBM22110([1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methy...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetAdenosylhomocysteine nucleosidase(Streptococcus pneumoniae)
Industrial Research

LigandPNGBDBM22110([1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methy...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  191nM ΔG°:  -38.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  280nM ΔG°:  -37.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Bovine)
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  360nM ΔG°:  -36.4kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  580nM ΔG°:  -35.2kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  1.29E+3nM ΔG°:  -33.3kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22105(7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

LigandPNGBDBM22103(7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed