Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 2990
TargetSerine/threonine-protein kinase pim-1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM26668(N-cyclohexyl-3-[3-(trifluoromethyl)phenyl]-[1,2,4]...)
Affinity DataKi:  11nM ΔG°:  -46.2kJ/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM26669(4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidi...)
Affinity DataKi:  91nM ΔG°:  -40.9kJ/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM26670(2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...)
Affinity DataKi:  550nM ΔG°:  -36.3kJ/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM26671(3-{[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino...)
Affinity DataKi:  3.40E+3nM ΔG°:  -31.7kJ/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM26672(2-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-y...)
Affinity DataKi:  4.50E+3nM ΔG°:  -31.0kJ/molepH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed