Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50022487
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235751({4-[2-((S)-1-amino-2-methyl-propyl)-4-methyl-pheny...)
Affinity DataEC50:  3.50E+3nMAssay Description:Agonist activity at MC4 receptor by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235750({4-[2-((S)-1-amino-2-methyl-propyl)-4-methyl-pheny...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at MC4 receptor by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235759((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-met...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235759((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-met...)
Affinity DataIC50: 93nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235764(cis-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphe...)
Affinity DataIC50: 310nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235752(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235767((2R,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataIC50: 640nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235763((2R,3R)-methyl 2-(1-(2-((S)-1-amino-2-methylpropyl...)
Affinity DataIC50: 720nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235788((4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)...)
Affinity DataIC50: 960nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235756((4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl)p...)
Affinity DataIC50: 1.50E+3nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235745((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at MC4 receptor assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235751({4-[2-((S)-1-amino-2-methyl-propyl)-4-methyl-pheny...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235759((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-met...)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235759((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-met...)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235776(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  7.20nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235752(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  11nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235752(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  11nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235767((2R,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataKi:  11nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235767((2R,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataKi:  11nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235755((2R,3R)-isopropyl 2-(1-(2-((S)-1-amino-2-methylpro...)
Affinity DataKi:  12nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235763((2R,3R)-methyl 2-(1-(2-((S)-1-amino-2-methylpropyl...)
Affinity DataKi:  17nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235753((2R,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataKi:  18nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235763((2R,3R)-methyl 2-(1-(2-((S)-1-amino-2-methylpropyl...)
Affinity DataKi:  18nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191011((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Affinity DataKi:  26nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191017((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Affinity DataKi:  31nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214694((R)-2-amino-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-...)
Affinity DataKi:  39nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235758((4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)...)
Affinity DataKi:  40nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235787((2S,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataKi:  42nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235770(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  45nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235764(cis-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphe...)
Affinity DataKi:  52nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235774(1-((2S,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  52nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235754((2S,3S)-methyl 2-(1-(2-((S)-1-amino-2-methylpropyl...)
Affinity DataKi:  53nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235765(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  54nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235760({4-[2-((S)-1-amino-2-methyl-propyl)-4-methyl-pheny...)
Affinity DataKi:  55nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235757((4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)...)
Affinity DataKi:  56nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235769((2S,3R)-methyl 2-(1-(2-((S)-1-amino-2-methylpropyl...)
Affinity DataKi:  59nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235748(1-((2S,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  62nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235771((2S,3R)-isopropyl 2-(1-(2-((S)-1-amino-2-methylpro...)
Affinity DataKi:  68nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189237((1S)-[2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-pip...)
Affinity DataKi:  74nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235761((2R,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataKi:  74nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235782(1-((2S,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  78nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235762(1-((2S,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  79nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235750({4-[2-((S)-1-amino-2-methyl-propyl)-4-methyl-pheny...)
Affinity DataKi:  92nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235773((2R,3R)-ethyl 2-(1-(2-((S)-1-amino-2-methylpropyl)...)
Affinity DataKi:  94nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235768((4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl)p...)
Affinity DataKi:  96nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235766(1-((2R,3R)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  97nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235786((4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorometh...)
Affinity DataKi:  98nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235775((4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)...)
Affinity DataKi:  110nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235772((4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)...)
Affinity DataKi:  110nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235784(1-((2S,3S)-2-(1-(2-((S)-1-amino-2-methylpropyl)-4-...)
Affinity DataKi:  120nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
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