Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50026275
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240153((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-1-(3-p...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244018(4'-(1-{[2-(6,7-Dimethyl-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244019(4'-[1-({2-[(3,4-Dichloro-phenyl)-(2-methoxy-ethyl)...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244020(4'-[1-({2-[Cyanomethyl-(3,4-dichloro-phenyl)-amino...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244021(4'-(1-{[2-(6,7-Dichloro-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244022(N-[1-(4'-Acetylamino-biphenyl-4-yl)-2-morpholin-4-...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244065(2-(6,7-Dichloro-3-oxo-2,3-dihydro-benzo[1,4]oxazin...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243921(N-(1-Biphenyl-4-yl-2-pyrrolidin-1-yl-ethyl)-2-[(3,...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243969(N-(1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-[(3,4...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243970((+/-)N-(1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-...)
Affinity DataEC50:  320nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243971(N-((R)-1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-(...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244017(N-((S)-1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-(...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50239135(2-((3,4-dichlorophenyl)(methyl)amino)-1-((2R,3R)-3...)
Affinity DataEC50:  6.30E+3nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241424(2-((3,4-dichlorophenyl)(methyl)amino)-1-((2S,3S)-3...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50007344(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyr...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243920((S)-2-((3,4-dichlorophenyl)(methyl)amino)-N-methyl...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243919((R)-2-((3,4-dichlorophenyl)(methyl)amino)-N-methyl...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243868((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-N-meth...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243868((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-N-meth...)
Affinity DataIC50: 160nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240153((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-1-(3-p...)
Affinity DataIC50: 750nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244065(2-(6,7-Dichloro-3-oxo-2,3-dihydro-benzo[1,4]oxazin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240153((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-1-(3-p...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243969(N-(1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-[(3,4...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244020(4'-[1-({2-[Cyanomethyl-(3,4-dichloro-phenyl)-amino...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244019(4'-[1-({2-[(3,4-Dichloro-phenyl)-(2-methoxy-ethyl)...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243868((+/-)-2-((3,4-dichlorophenyl)(methyl)amino)-N-meth...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244020(4'-[1-({2-[Cyanomethyl-(3,4-dichloro-phenyl)-amino...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244017(N-((S)-1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-(...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243970((+/-)N-(1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243921(N-(1-Biphenyl-4-yl-2-pyrrolidin-1-yl-ethyl)-2-[(3,...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244021(4'-(1-{[2-(6,7-Dichloro-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243921(N-(1-Biphenyl-4-yl-2-pyrrolidin-1-yl-ethyl)-2-[(3,...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244019(4'-[1-({2-[(3,4-Dichloro-phenyl)-(2-methoxy-ethyl)...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244022(N-[1-(4'-Acetylamino-biphenyl-4-yl)-2-morpholin-4-...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244018(4'-(1-{[2-(6,7-Dimethyl-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243971(N-((R)-1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-(...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243969(N-(1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-[(3,4...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244065(2-(6,7-Dichloro-3-oxo-2,3-dihydro-benzo[1,4]oxazin...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244022(N-[1-(4'-Acetylamino-biphenyl-4-yl)-2-morpholin-4-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244018(4'-(1-{[2-(6,7-Dimethyl-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243971(N-((R)-1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-(...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244017(N-((S)-1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-(...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244021(4'-(1-{[2-(6,7-Dichloro-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243970((+/-)N-(1-Biphenyl-4-yl-2-morpholin-4-yl-ethyl)-2-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244020(4'-[1-({2-[Cyanomethyl-(3,4-dichloro-phenyl)-amino...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244019(4'-[1-({2-[(3,4-Dichloro-phenyl)-(2-methoxy-ethyl)...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244022(N-[1-(4'-Acetylamino-biphenyl-4-yl)-2-morpholin-4-...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244021(4'-(1-{[2-(6,7-Dichloro-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244065(2-(6,7-Dichloro-3-oxo-2,3-dihydro-benzo[1,4]oxazin...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244018(4'-(1-{[2-(6,7-Dimethyl-2-oxo-2H-quinoxalin-1-yl)-...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human urotensin-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Displayed 1 to 50 (of 62 total ) | Next | Last >>
Jump to: