Compile Data Set for Download or QSAR
Report error Found 126 Enz. Inhib. hit(s) with all data for entry = 50038670
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 12nMAssay Description:Inhibition of serotonin uptake at human cloned SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50: 14nMAssay Description:Inhibition of serotonin uptake at human cloned SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of norepinephrine uptake at human cloned NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 23nMAssay Description:Inhibition of norepinephrine uptake at human cloned NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50: 27nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243939((cis)-1-(3,4-dichlorophenyl)-6-methyl-3-aza-bicycl...)
Affinity DataIC50: 29nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244081((1S,5S)-1-(5-fluorobenzo[b]thiophen-2-yl)-3-aza-bi...)
Affinity DataIC50: 33nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243940((cis)-1-(3,4-dichlorophenyl)-6-phenyl-3-aza-bicycl...)
Affinity DataIC50: 34nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243942(1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 36nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243986(1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 48nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243942(1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 51nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243987(1-(benzo[b]thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 53nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243896((1S,5R)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 66nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244081((1S,5S)-1-(5-fluorobenzo[b]thiophen-2-yl)-3-aza-bi...)
Affinity DataIC50: 67nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243987(1-(benzo[b]thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 71nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243988(1-(benzo[b]thiophen-3-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 73nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244040((1S,5S)-1-(5-chlorothiophen-2-yl)-3-aza-bicyclo[3....)
Affinity DataIC50: 77nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50: 78nMAssay Description:Inhibition of dopamine uptake at human cloned DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244040((1S,5S)-1-(5-chlorothiophen-2-yl)-3-aza-bicyclo[3....)
Affinity DataIC50: 81nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50: 88nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243991((1S,5S)-1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 92nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 96nMAssay Description:Inhibition of dopamine uptake at human cloned DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244048((1S,5R)-1-(2,3-dihydro-1H-inden-5-yl)-3-aza-bicycl...)
Affinity DataIC50: 97nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243896((1S,5R)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 103nMAssay Description:Inhibition of norepinephrine uptake at human cloned NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243894((cis)-1,6-diphenyl-3-aza-bicyclo[3.1.0]hexane | CH...)
Affinity DataIC50: 120nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243896((1S,5R)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 129nMAssay Description:Inhibition of dopamine uptake at human cloned DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243989(1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane | CHE...)
Affinity DataIC50: 130nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244082(1-(5-chlorothiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 130nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243896((1S,5R)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 133nMAssay Description:Inhibition of serotonin uptake at human cloned SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244041(1-(5-bromothiophen-2-yl)-3-aza-bicyclo[3.1.0]hexan...)
Affinity DataIC50: 140nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243986(1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 140nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243990((1R,5R)-1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 150nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243889((cis)-2-methyl-1-(thiophen-2-yl)-3-aza-bicyclo[3.1...)
Affinity DataIC50: 150nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243943(1-Biphenyl-4-yl-3-aza-bicyclo[3.1.0]hexane | CHEMB...)
Affinity DataIC50: 160nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243987(1-(benzo[b]thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 180nMAssay Description:Inhibition of dopamine uptake at cloned DAT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244044(1-(5-(trifluoromethyl)thiophen-2-yl)-3-aza-bicyclo...)
Affinity DataIC50: 190nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244041(1-(5-bromothiophen-2-yl)-3-aza-bicyclo[3.1.0]hexan...)
Affinity DataIC50: 190nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243939((cis)-1-(3,4-dichlorophenyl)-6-methyl-3-aza-bicycl...)
Affinity DataIC50: 190nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244082(1-(5-chlorothiophen-2-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 190nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243942(1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane | C...)
Affinity DataIC50: 190nMAssay Description:Inhibition of dopamine uptake at cloned DAT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243938((trans)-1-(3,4-dichlorophenyl)-6-methyl-3-aza-bicy...)
Affinity DataIC50: 200nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243988(1-(benzo[b]thiophen-3-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 220nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243894((cis)-1,6-diphenyl-3-aza-bicyclo[3.1.0]hexane | CH...)
Affinity DataIC50: 240nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243937((1R,5S)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 260nMAssay Description:Inhibition of dopamine uptake at cloned DAT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50244046((1S,5R)-1-(thiophen-3-yl)-3-aza-bicyclo[3.1.0]hexa...)
Affinity DataIC50: 300nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243992((trans)-4-methyl-1-(thiophen-2-yl)-3-aza-bicyclo[3...)
Affinity DataIC50: 320nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50243896((1S,5R)-1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0...)
Affinity DataIC50: 330nMAssay Description:Inhibition of dopamine uptake at cloned DAT in rat brain synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
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