Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50026752
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273175(N-(2-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273022(1-(2,3-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273058(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273024(1-(3,4-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273058(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273022(1-(2,3-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272980(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272856(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataKi:  65nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272979(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272900(1-(2-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataKi:  71nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272982(1-(2-isopropylphenyl)-N-(3-oxo-3,4-dihydro-2H-benz...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272983(1-(2-bromo-3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H...)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272858(1-(3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273023(1-(4-tert-butylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272899(1-(2-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272859(1-(3-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  97nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273021(1-(3-chloro-2-methylphenyl)-N-(3-oxo-3,4-dihydro-2...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273021(1-(3-chloro-2-methylphenyl)-N-(3-oxo-3,4-dihydro-2...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272981(1-(2-ethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272983(1-(2-bromo-3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H...)
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273057(1-(3,5-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  137nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273023(1-(4-tert-butylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  142nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272981(1-(2-ethylphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272980(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272900(1-(2-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272982(1-(2-isopropylphenyl)-N-(3-oxo-3,4-dihydro-2H-benz...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272856(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272859(1-(3-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272899(1-(2-chlorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272897(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataKi:  225nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272820(N-(1H-indol-4-yl)-1-(3-(trifluoromethyl)phenyl)pip...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273025(1-(3,4-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataKi:  314nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272860(1-(3-bromophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b]...)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273057(1-(3,5-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataIC50: 370nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273025(1-(3,4-dimethylphenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272979(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272897(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 490nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272858(1-(3-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272784(N-(quinolin-3-yl)-1-(3-(trifluoromethyl)phenyl)pip...)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272898(1-(2-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 670nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272818(N-(1-acetylindolin-6-yl)-1-(3-(trifluoromethyl)phe...)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273024(1-(3,4-difluorophenyl)-N-(3-oxo-3,4-dihydro-2H-ben...)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273093(ethyl 2-methyl-3-oxo-6-(1-(3,4,5-trifluorophenyl)p...)
Affinity DataIC50: 870nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273129(methyl 2-(3-oxo-6-(1-(3,4,5-trifluorophenyl)piperi...)
Affinity DataIC50: 890nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272821(N-(1H-indol-5-yl)-1-(3-(trifluoromethyl)phenyl)pip...)
Affinity DataIC50: 1.07E+3nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272896(1-(3-methoxyphenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[...)
Affinity DataIC50: 1.42E+3nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272898(1-(2-fluorophenyl)-N-(3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataKi:  1.47E+3nMAssay Description:Displacement of [3H]RTX from human TRPV1 receptor expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272857(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-...)
Affinity DataIC50: 1.81E+3nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273092(N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)...)
Affinity DataIC50: 1.96E+3nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273175(N-(2-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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