Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 3586
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31044(1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...)
Affinity DataKd:  308nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataEC50:  4.27E+3nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31040(1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...)
Affinity DataEC50:  1.72E+3nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31044(1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...)
Affinity DataEC50:  1.21E+3nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataEC50:  690nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM34905(1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...)
Affinity DataEC50:  917nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM34671(1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...)
Affinity DataEC50:  946nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataKd:  566nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31040(1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...)
Affinity DataKd:  928nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM34671(1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...)
Affinity DataKd:  492nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataKd:  1.00E+3nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM34905(1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...)
Affinity DataKd:  202nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM34671(1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...)
Affinity DataKd:  365nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM36528(3-benzyl-1-ethyl-6-methyl-1H,5H,6H,7H-pyrimido[5,4...)
Affinity DataKd:  182nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31040(1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4...)
Affinity DataKd:  360nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31044(1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...)
Affinity DataKd:  365nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM36527(1,6-dimethyl-3-phenyl-1H,5H,6H,7H-pyrimido[5,4-e][...)
Affinity DataKd:  585nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM34905(1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...)
Affinity DataKd:  414nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed