Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50027223
LigandPNGBDBM50266072((+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1...)
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266101((+/-)-N-(2-(4-chlorophenyl)-1-(5-methyl-1,2,4-oxad...)
Affinity DataIC50: 8nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266127((+/-)-N-(1-(4-chlorophenyl)-3-methoxypropan-2-yl)-...)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266129((+/-)-N-(1-(4-chlorophenyl)-3-(dimethylamino)propa...)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266099((+/-)-methyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)b...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266129((+/-)-N-(1-(4-chlorophenyl)-3-(dimethylamino)propa...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266130((+/-)-N-(1-(4-chlorophenyl)-3-(dimethylamino)propa...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266127((+/-)-N-(1-(4-chlorophenyl)-3-methoxypropan-2-yl)-...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266130((+/-)-N-(1-(4-chlorophenyl)-3-(dimethylamino)propa...)
Affinity DataIC50: 27nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266072((+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266101((+/-)-N-(2-(4-chlorophenyl)-1-(5-methyl-1,2,4-oxad...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266128((+/-)-N-(1-(4-chlorophenyl)-3-oxobutan-2-yl)-N-(1,...)
Affinity DataIC50: 45nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266205(2-(benzo[b]thiophen-3-yl)-5-(cyclohexylmethyl)-1-(...)
Affinity DataIC50: 47nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266169(5-(4-chlorobenzyl)-2-(naphthalen-1-yl)-1-(1,4-diox...)
Affinity DataIC50: 90nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266207(2-(benzo[b]thiophen-3-yl)-5-(4-chlorobenzyl)-4-met...)
Affinity DataIC50: 90nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266071(N-(4-chlorophenethyl)-N-((1r,4r)-4-hydroxycyclohex...)
Affinity DataIC50: 125nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266099((+/-)-methyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)b...)
Affinity DataIC50: 172nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266167(N-((S)-1-(4-chlorophenyl)-4-morpholinobutan-2-yl)-...)
Affinity DataIC50: 200nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266242(2-(benzo[b]thiophen-3-yl)-7-chloro-1-(1,4-dioxaspi...)
Affinity DataIC50: 325nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266100((+/-)-3-(4-chlorophenyl)-2-(2-ethyl-N-(1,4-dioxasp...)
Affinity DataIC50: 350nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266204(2-(benzo[b]thiophen-3-yl)-5-(4-chlorobenzyl)-1-(1,...)
Affinity DataIC50: 500nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266168((+/-)-N-(4-chlorophenethyl)-2-((dimethylamino)meth...)
Affinity DataIC50: 500nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266241(2-(benzo[b]thiophen-3-yl)-6,7-dichloro-1-(1,4-diox...)
Affinity DataIC50: 790nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266205(2-(benzo[b]thiophen-3-yl)-5-(cyclohexylmethyl)-1-(...)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266169(5-(4-chlorobenzyl)-2-(naphthalen-1-yl)-1-(1,4-diox...)
Affinity DataIC50: 877nMAssay Description:Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266239(3-(4-chlorobenzyl)-5-(naphthalen-1-yl)-4-(1,4-diox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266206(5-(4-chlorobenzyl)-2-(3-methoxyphenyl)-1-(1,4-diox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266166(N-((S)-1-(4-chlorophenyl)-4-(dimethylamino)butan-2...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266098((+/-)-N-(1-(4-chlorophenyl)-3-hydroxypropan-2-yl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50266240(2-(benzo[b]thiophen-3-yl)-5-(4-chlorobenzyl)-1-(1,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed