Compile Data Set for Download or QSAR
Report error Found 88 Enz. Inhib. hit(s) with all data for entry = 50027453
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246312((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246273((R)-2-(3-(2-amino-2-oxoethyl)-4,6-dimethyl-2-oxo-2...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246271((R)-methyl 2-(5,7-dimethyl-3-(2-(3-methyl-2,5-diox...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246474(2-{9-methyl-2,10-dioxo-1,3,9-triazatricyclo[6.5.1....)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246228((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246314((R)-2-(4,6-dimethyl-2-oxo-3-(pyridin-2-yl)-2,3-dih...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246424(2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246084((R)-2-(4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]i...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246271((R)-methyl 2-(5,7-dimethyl-3-(2-(3-methyl-2,5-diox...)
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246423((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246178((R)-2-(6-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataKi:  9.5nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246421((R)-N,N-dimethyl-4-(3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataKi:  9.60nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246228((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246312((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246474(2-{9-methyl-2,10-dioxo-1,3,9-triazatricyclo[6.5.1....)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246273((R)-2-(3-(2-amino-2-oxoethyl)-4,6-dimethyl-2-oxo-2...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246086((R)-2-(4-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246368((R)-4-(3-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro...)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246474(2-{9-methyl-2,10-dioxo-1,3,9-triazatricyclo[6.5.1....)
Affinity DataIC50: 13nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246312((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246424(2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246130((R)-2-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246225((R)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246175((R)-2-(5-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50195956(N-[(4R)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imid...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246272((S)-methyl 2-(5,7-dimethyl-3-(2-((R)-3-methyl-2,5-...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246424(2-{2,10-dioxo-1,3,9-triazatricyclo[6.5.1.0^{4,14}]...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246365((R)-N,N-dimethyl-2-(3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246084((R)-2-(4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]i...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246312((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246177((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246421((R)-N,N-dimethyl-4-(3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246313((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246314((R)-2-(4,6-dimethyl-2-oxo-3-(pyridin-2-yl)-2,3-dih...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246128((R)-2-(4-methoxy-2-oxo-2,3-dihydro-1H-benzo[d]imid...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246421((R)-N,N-dimethyl-4-(3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246366((R)-3-(3-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro...)
Affinity DataKi:  31nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246423((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246127((R)-2-(4-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataKi:  32nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246367((R)-N,N-dimethyl-3-(3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataKi:  36nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246315((R)-2-(3-(2-amino-2-oxoethyl)-2-oxo-2,3-dihydro-1H...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50195960((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246085((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]hCGRP from human cloned CGRP receptor expressed in HEK93 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246086((R)-2-(4-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imida...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246368((R)-4-(3-(2-(3-methyl-2,5-dioxo-1',3'-dihydrospiro...)
Affinity DataIC50: 43nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246313((R)-2-(5,7-dimethyl-3-(2-(3-methyl-2,5-dioxo-1',3'...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50246085((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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