Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50038762
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataKi:  0.0858nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255901(1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(met...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255135(1-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255898(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-1...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255900(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255134(2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255955(2-(1-Benzofuran-2-yl)-1-[1-(1-methylcyclooctyl)pip...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataKi:  0.590nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255956(1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(tri...)
Affinity DataKi:  0.630nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataKi:  1.10nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255135(1-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255898(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-1...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004178(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255901(1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(met...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255900(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255954(2-(1H-Indol-6-yl)-1-[1-(1-methylcyclooctyl)piperid...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255136(2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclo...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255137(1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzim...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255134(2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255955(2-(1-Benzofuran-2-yl)-1-[1-(1-methylcyclooctyl)pip...)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255898(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-1...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255956(1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(tri...)
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255136(2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclo...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255901(1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(met...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataEC50:  8.40nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255134(2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255900(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255900(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255134(2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataKi:  11nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255137(1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzim...)
Affinity DataKi:  11nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255954(2-(1H-Indol-6-yl)-1-[1-(1-methylcyclooctyl)piperid...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255900(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255136(2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclo...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255136(2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclo...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255135(1-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255136(2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclo...)
Affinity DataKi:  21nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255899(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255898(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-1...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255850(1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3...)
Affinity DataEC50:  34nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255134(2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataKi:  43nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255953(2-(3-Chloro-4-fluorophenyl)-1-[1-(1-methylcyclooct...)
Affinity DataKi:  45nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50255134(2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
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