Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50004171
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479674(CHEMBL482359)
Affinity DataEC50:  1.62E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479679(CHEMBL506313)
Affinity DataEC50:  5.93E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479676(CHEMBL509581)
Affinity DataEC50:  8.23E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479677(CHEMBL482200)
Affinity DataEC50:  3.87E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479675(CHEMBL473567)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  1.14E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479673(CHEMBL467525)
Affinity DataEC50:  6.14E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to alpha2 adrenoceptor in human cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479675(CHEMBL473567)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479673(CHEMBL467525)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479674(CHEMBL482359)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479676(CHEMBL509581)
Affinity DataKi:  112nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479679(CHEMBL506313)
Affinity DataKi:  178nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM50479678(CHEMBL498849)
Affinity DataKi:  263nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed