Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50028300
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257892(6-(pyridin-3-yl)-1,6-diazaspiro[3.4]octane | CHEMB...)
Affinity DataEC50:  2.50E+4nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257943(2-(pyridin-3-yl)-2,7-diazaspiro[4.4]nonane | CHEMB...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257942(2-(6-chloropyridin-3-yl)-2,7-diazaspiro[4.4]nonane...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257941(7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane | CHEMB...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257893(7-(6-chloropyridin-3-yl)-1,7-diazaspiro[4.4]nonane...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257892(6-(pyridin-3-yl)-1,6-diazaspiro[3.4]octane | CHEMB...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257891(6-(6-chloropyridin-3-yl)-1,6-diazaspiro[3.4]octane...)
Affinity DataEC50:  6.90E+3nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257890(3-(pyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane | ...)
Affinity DataEC50:  6.10E+3nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50216347((1S,4S)-2-(3-pyridinyl)-2,5-diazabicyclo[2.2.1]hep...)
Affinity DataEC50:  6.40E+3nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062641(CHEMBL430497 | 5-((R)-1-Azetidin-2-ylmethoxy)-2-ch...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  9.40E+3nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257943(2-(pyridin-3-yl)-2,7-diazaspiro[4.4]nonane | CHEMB...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257942(2-(6-chloropyridin-3-yl)-2,7-diazaspiro[4.4]nonane...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257941(7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane | CHEMB...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257893(7-(6-chloropyridin-3-yl)-1,7-diazaspiro[4.4]nonane...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257891(6-(6-chloropyridin-3-yl)-1,6-diazaspiro[3.4]octane...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257890(3-(pyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane | ...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062641(CHEMBL430497 | 5-((R)-1-Azetidin-2-ylmethoxy)-2-ch...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0470nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062641(CHEMBL430497 | 5-((R)-1-Azetidin-2-ylmethoxy)-2-ch...)
Affinity DataKi:  0.0480nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50216347((1S,4S)-2-(3-pyridinyl)-2,5-diazabicyclo[2.2.1]hep...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257890(3-(pyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane | ...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257892(6-(pyridin-3-yl)-1,6-diazaspiro[3.4]octane | CHEMB...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257891(6-(6-chloropyridin-3-yl)-1,6-diazaspiro[3.4]octane...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257941(7-(pyridin-3-yl)-1,7-diazaspiro[4.4]nonane | CHEMB...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257893(7-(6-chloropyridin-3-yl)-1,7-diazaspiro[4.4]nonane...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257943(2-(pyridin-3-yl)-2,7-diazaspiro[4.4]nonane | CHEMB...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50257942(2-(6-chloropyridin-3-yl)-2,7-diazaspiro[4.4]nonane...)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed