Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 3129
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28480((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28481((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28481((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Affinity DataIC50: 1.10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50: 1.30nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28479((2S)-2-({12-[(cyclopentylcarbamoyl)amino]-8-oxatri...)
Affinity DataIC50: 2.10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28473((2S)-2-[(12-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Affinity DataIC50: 2.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28480((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Affinity DataIC50: 3.30nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28472((2S)-3-methyl-2-[(12-{[(2-methylpropoxy)carbonyl]a...)
Affinity DataIC50: 4.70nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28479((2S)-2-({12-[(cyclopentylcarbamoyl)amino]-8-oxatri...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28470((2S)-2-({12-[(ethoxycarbonyl)amino]-8-oxatricyclo[...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28471((2S)-3-methyl-2-({12-[(propoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 5.60nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28475((2S)-2-({12-[(2-chlorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50: 6.60nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28463((2R)-2-({11-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50: 7.20nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28478((2S)-2-{[12-(carbamoylamino)-8-oxatricyclo[7.4.0.0...)
Affinity DataIC50: 7.60nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50: 8.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28483((2S)-2-[(11-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28471((2S)-3-methyl-2-({12-[(propoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28472((2S)-3-methyl-2-[(12-{[(2-methylpropoxy)carbonyl]a...)
Affinity DataIC50: 10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28473((2S)-2-[(12-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Affinity DataIC50: 10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28474((2S)-3-methyl-2-({12-[(phenoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 10.2nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28461((2S)-2-({12-methanesulfonamido-8-oxatricyclo[7.4.0...)
Affinity DataIC50: 10.3nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28456((2R)-2-({11-methanesulfonamido-8-oxatricyclo[7.4.0...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28482((2S)-2-({11-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50: 14nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28477((2S)-3-methyl-2-({12-[(4-methylphenoxycarbonyl)ami...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28464((2R)-3-methyl-2-({11-[(propoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28484((2S)-2-({11-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28486((2R)-3-methyl-2-{8-oxatricyclo[7.4.0.0^{2,7}]tride...)
Affinity DataIC50: 38nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28465((2R)-3-methyl-2-[(11-{[(propan-2-yloxy)carbonyl]am...)
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28466((2R)-3-methyl-2-({11-[(phenoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28458((2R)-3-methyl-2-{[11-(propane-2-sulfonamido)-8-oxa...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28478((2S)-2-{[12-(carbamoylamino)-8-oxatricyclo[7.4.0.0...)
Affinity DataIC50: 59nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28462((2S)-3-methyl-2-{[12-(2,2,2-trifluoroethane-1-sulf...)
Affinity DataIC50: 70nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28461((2S)-2-({12-methanesulfonamido-8-oxatricyclo[7.4.0...)
Affinity DataIC50: 93nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28483((2S)-2-[(11-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Affinity DataIC50: 97nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28460((2R)-2-({11-benzenesulfonamido-8-oxatricyclo[7.4.0...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28477((2S)-3-methyl-2-({12-[(4-methylphenoxycarbonyl)ami...)
Affinity DataIC50: 100nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28470((2S)-2-({12-[(ethoxycarbonyl)amino]-8-oxatricyclo[...)
Affinity DataIC50: 100nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28464((2R)-3-methyl-2-({11-[(propoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 109nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50: 120nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28458((2R)-3-methyl-2-{[11-(propane-2-sulfonamido)-8-oxa...)
Affinity DataIC50: 120nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28457((2S)-2-({11-methanesulfonamido-8-oxatricyclo[7.4.0...)
Affinity DataIC50: 170nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28475((2S)-2-({12-[(2-chlorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50: 180nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50: 200nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28474((2S)-3-methyl-2-({12-[(phenoxycarbonyl)amino]-8-ox...)
Affinity DataIC50: 220nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28484((2S)-2-({11-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50: 361nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28465((2R)-3-methyl-2-[(11-{[(propan-2-yloxy)carbonyl]am...)
Affinity DataIC50: 500nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM28463((2R)-2-({11-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50: 500nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Wyeth Research

LigandPNGBDBM28487((2S)-3-methyl-2-{8-oxatricyclo[7.4.0.0^{2,7}]tride...)
Affinity DataIC50: 600nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
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