Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50030412
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295819(12,13-(2,3-cis-dihydroxy-butan-1,4-yl)-12,13-dihyd...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295821(12,13-(2-hydroxy-butan-1,4-yl)-12,13-dihydro-5,7-d...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295820(12,13-(2-hydroxy-pentan-1,5-yl)-12,13-dihydro-5,7-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295818(12,13-(2,3-cis-dihydroxy-pentan-1,5-yl)-12,13-dihy...)
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295817(12,13-[2-carboxy-cis-2,3-dihydroxy-1,4-butyl]-6,7,...)
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295812(12,13-(3,4-Cis-dihyroxy-1,6-hexyl)-6,7,12,13-tetra...)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295816((16S,17R)-16-{[3-(dimethylamino)pyrrolidin-1-yl]ca...)
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295814(12,13-(1,4-but-cis-2-enyl)-6,7,12,13-tetrahydro-5-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295813(12,13-(1,6-hex-cis-3-enyl)-6,7,12,13-tetrahydro-5-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2581(CHEMBL16958 | 3,13,23-triazahexacyclo[14.7.0.0^{2,...)
Affinity DataIC50: 61nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295815(12,13-diallyl-6,7,12,13-tetrahydro-5-oxo-5H-indolo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: 300nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: 300nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: 540nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 5A(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: 689nMAssay Description:Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed