Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50028851
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243165(5-(2-p-tolylethynyl)pyrimidine | 5-(p-tolylethynyl...)
Affinity DataEC50:  3.30E+3nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataEC50:  1.43E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278925(N-methyl-5-(m-tolylethynyl)pyrimidin-2-amine | CHE...)
Affinity DataEC50:  2.11E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278926(2-(methylthio)-5-(phenylethynyl)pyrimidine | CHEMB...)
Affinity DataEC50:  1.20E+5nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278927(2-tert-butyl-5-(phenylethynyl)pyrimidine | CHEMBL4...)
Affinity DataEC50:  2.47E+5nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278928(N-methyl-5-(p-tolylethynyl)pyrimidin-2-amine | CHE...)
Affinity DataEC50:  7.04E+5nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243109(5-(m-tolylethynyl)pyrimidine | 5-(2-m-tolylethynyl...)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278923(2-ethoxy-5-(m-tolylethynyl)pyrimidine | CHEMBL4968...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278929(2-(phenylethynyl)pyrimidine | CHEMBL450465)
Affinity DataIC50: 195nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243108(5-(phenylethynyl)pyrimidine | CHEMBL486244)
Affinity DataIC50: 486nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu8 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278954(2-(p-tolylethynyl)pyrimidine | CHEMBL497930)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed