Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50030447
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296293(1-((3S)-1-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-2...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296274((S)-2-cyano-1-(7-fluoro-2-methylbenzofuran-5-yl)-3...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296286(1-((3S)-1-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-2-oxo...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296287(1-((3S)-1-(2-(2-benzylpyrrolidin-1-yl)-2-oxoethyl)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296278((S)-2-cyano-1-(2,7-dimethylbenzofuran-5-yl)-3-(2-o...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296290(1-((S)-1-(2-((R)-2-(aminomethyl)pyrrolidin-1-yl)-2...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296277((S)-1-(7-chloro-2-methylbenzofuran-5-yl)-2-cyano-3...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296292(N-(((R)-1-(2-((S)-3-((Z)-2-cyano-3-(2-methylbenzof...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM26351(CHEMBL196803 | 2-{[(2-methyl-1-benzofuran-5-yl)ami...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296288(1-((3S)-1-(2-(3-benzylpyrrolidin-1-yl)-2-oxoethyl)...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296291(N-(((S)-1-(2-((S)-3-((Z)-2-cyano-3-(2-methylbenzof...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296276((S)-2-cyano-1-(6-fluoro-2-methylbenzofuran-5-yl)-3...)
Affinity DataIC50: 76nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296269((S)-1-(benzofuran-5-yl)-2-cyano-3-(2-oxo-1-(2-oxo-...)
Affinity DataIC50: 84nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM26350(3-(3-methylphenyl)-1-[(3S)-2-oxo-1-[2-oxo-2-(pyrro...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296279((S)-2-cyano-1-(2-methyl-7-(trifluoromethyl)benzofu...)
Affinity DataIC50: 167nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296285((+/-)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296273((S)-2-cyano-1-(2,3-dimethylbenzofuran-5-yl)-3-(2-o...)
Affinity DataIC50: 349nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296289(1-((S)-1-(2-((S)-2-(aminomethyl)pyrrolidin-1-yl)-2...)
Affinity DataIC50: 386nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296259((S)-2-cyano-1-(naphthalen-2-yl)-3-(2-oxo-1-(2-oxo-...)
Affinity DataIC50: 780nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296283((S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1...)
Affinity DataIC50: 928nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296284((R)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1...)
Affinity DataIC50: 940nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296267((S)-2-cyano-1-(2-methyl-1H-indol-6-yl)-3-(2-oxo-1-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296268((S)-2-cyano-1-(2-methyl-2H-indazol-5-yl)-3-(2-oxo-...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296271((S)-2-cyano-1-(2-cyanobenzofuran-5-yl)-3-(2-oxo-1-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296262((S)-2-cyano-1-(2-methylbenzo[d]oxazol-5-yl)-3-(2-o...)
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296275((S)-2-cyano-1-(4-fluoro-2-methylbenzofuran-5-yl)-3...)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296260((S)-2-cyano-1-(2-methylbenzo[b]thiophen-5-yl)-3-(2...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296272((S)-2-cyano-1-(3-methylbenzofuran-5-yl)-3-(2-oxo-1...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of t-PAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >7.80E+3nMAssay Description:Inhibition of u-PAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296265((S)-2-cyano-1-(2-methyl-1H-benzo[d]imidazol-5-yl)-...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296280((S)-2-cyano-1-(7-methoxy-2-methylbenzofuran-5-yl)-...)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296270((S)-2-cyano-1-(2-ethylbenzofuran-5-yl)-3-(2-oxo-1-...)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >1.60E+4nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >1.80E+4nMAssay Description:Inhibition of activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of CYP3A4 using BFC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296263((S)-2-cyano-1-(2-methylbenzo[d]oxazol-6-yl)-3-(2-o...)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296282((R)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296281((S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296261((S)-2-cyano-1-(2-methylbenzofuran-6-yl)-3-(2-oxo-1...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296266((S)-2-cyano-1-(2-methylimidazo[1,2-a]pyridin-6-yl)...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296264((S)-2-cyano-1-(2-methyl-1H-indol-5-yl)-3-(2-oxo-1-...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human factor 10a-mediated cleavage of synthetic substrate S-2222More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
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