Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50030369
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295219(2-(4-methyl-1,4-diazepane-1-carbonyl)pyrazolo[1,5-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295217(2-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]quinazoli...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295218(2-(1,4-diazepane-1-carbonyl)pyrazolo[1,5-a]quinazo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295216(N-((1-methylpiperidin-4-yl)methyl)-5-oxo-4,5-dihyd...)
Affinity DataIC50: 70nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295215(N-((1-methylpyrrolidin-3-yl)methyl)-5-oxo-4,5-dihy...)
Affinity DataIC50: 80nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295214(N-(2-(1-morpholinocyclopentyl)ethyl)-5-oxo-4,5-dih...)
Affinity DataIC50: 90nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295211(2-phenylpyrazolo[1,5-a]quinazolin-5(4H)-one | CHEM...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295212(2-(2,3-dimethoxyphenyl)pyrazolo[1,5-a]quinazolin-5...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295213(N-(2-(dimethylamino)ethyl)-N-methyl-5-oxo-4,5-dihy...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295209(N-(3-morpholinopropyl)-5-oxo-4,5-dihydropyrazolo[1...)
Affinity DataIC50: 140nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295210(N-(2-morpholinoethyl)-5-oxo-4,5-dihydropyrazolo[1,...)
Affinity DataIC50: 140nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295208(2-(thiophen-2-yl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50: 150nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295177(2-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]quinazolin-5...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295178(2-cyclohexylpyrazolo[1,5-a]quinazolin-5(4H)-one | ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295175(2-(furan-2-yl)pyrazolo[1,5-a]quinazolin-5(4H)-one ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295176(2-(2,4-dimethoxyphenyl)pyrazolo[1,5-a]quinazolin-5...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295179(2-(4-(cyclopropylmethyl)piperazine-1-carbonyl)pyra...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295180(2-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]qu...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295181(2-methylpyrazolo[1,5-a]quinazolin-5(4H)-one | CHEM...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295182(2-isobutylpyrazolo[1,5-a]quinazolin-5(4H)-one | CH...)
Affinity DataIC50: 400nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295183((S)-2-(3-(octahydropyrrolo[1,2-a]pyrazine-2-carbon...)
Affinity DataIC50: 500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295184(2-(4-chlorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295187(2-p-tolylpyrazolo[1,5-a]quinazolin-5(4H)-one | CHE...)
Affinity DataIC50: 500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295185(2-(3-chlorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295186(2-(4-ethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50: 500nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295188((S)-2-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295189(2-(3-bromophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295191(2-(4-bromophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-o...)
Affinity DataIC50: 700nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295190(2-(3-(morpholinomethyl)piperidine-1-carbonyl)pyraz...)
Affinity DataIC50: 700nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295192(N-(2-(dimethylamino)ethyl)-N-methyl-3-(5-oxo-4,5-d...)
Affinity DataIC50: 800nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295195(3-(4-methyl-1,4-diazepane-1-carbonyl)pyrazolo[1,5-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295196(3-(4-methylpiperazine-1-carbonyl)pyrazolo[1,5-a]qu...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295193(N-(2-morpholinoethyl)-5-oxo-4,5-dihydropyrazolo[1,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295194(3-(1,4-diazepane-1-carbonyl)pyrazolo[1,5-a]quinazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295197(2-(3-(4-methylpiperazine-1-carbonyl)phenyl)pyrazol...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295203(2-(4-(trifluoromethoxy)phenyl)pyrazolo[1,5-a]quina...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295204(2-(4-fluorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295202(4-(5-oxo-4,5-dihydropyrazolo[1,5-a]quinazolin-2-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295207(2-(4-propylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295205(2-(3-fluorophenyl)pyrazolo[1,5-a]quinazolin-5(4H)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295206(2-(4-tert-butylphenyl)pyrazolo[1,5-a]quinazolin-5(...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295198(2-(4-(morpholinomethyl)piperidine-1-carbonyl)pyraz...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295199(N-(2-(dimethylamino)ethyl)-N-methyl-4-(5-oxo-4,5-d...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295200(2-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyrazol...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50295201((S)-2-(4-(octahydropyrrolo[1,2-a]pyrazine-2-carbon...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed