Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50038898
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296352(1-(8-(3-(4-methylpiperazin-1-yl)cyclobutyl)-2-phen...)
Affinity DataIC50: 19nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296353(1-(8-(3-(aziridin-1-yl)cyclobutyl)-2-phenylquinoli...)
Affinity DataIC50: 20nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296355(N-(2-(5-(3,5-difluorophenylsulfonyl)-4,5,6,7-tetra...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human GST-tagged IGF1R by trans-phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350(BMS-554417 | (S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-...)
Affinity DataIC50: 51nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM4293((2E)-3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphen...)
Affinity DataIC50: 61nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350(BMS-554417 | (S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-...)
Affinity DataIC50: 68nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...)
Affinity DataIC50: 73nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296355(N-(2-(5-(3,5-difluorophenylsulfonyl)-4,5,6,7-tetra...)
Affinity DataIC50: 80nMAssay Description:Inhibition of IGF1R in human MCF7 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 86nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296356(N-(5-(5-(3,5-difluorophenylsulfonyl)-6,6-dimethyl-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of GST-tagged human IGF1R expressed in baculovirus-infected Sf21 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350(BMS-554417 | (S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-...)
Affinity DataIC50: 94nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...)
Affinity DataIC50: 150nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296357(4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296356(N-(5-(5-(3,5-difluorophenylsulfonyl)-6,6-dimethyl-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of IGF1R in IGF1-stimulated human MCF7 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296354(N-(5-(3,5-difluorophenylsulfonyl)-4,5,6,7-tetrahyd...)
Affinity DataIC50: 340nMAssay Description:Inhibition of IGF1R in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(CHEMBL401930 | 4-{[(2S)-2-(3-chlorophenyl)-2-hydro...)
Affinity DataIC50: 341nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296351((R)-4-(2-(2-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50: 830nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50230005(TCMDC-125497 | 1-(5-chloro-2-methoxyphenyl)-3-(2-m...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IGF1R in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350(BMS-554417 | (S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296354(N-(5-(3,5-difluorophenylsulfonyl)-4,5,6,7-tetrahyd...)
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition for IGF1R-induced S6 ribosomal protein phosphorylation in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50201127(3-(5-(1H-imidazol-1-yl)-7-methyl-1H-benzo[d]imidaz...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50271906(6-benzyl-N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCR-ABL p210More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCR-ABL p210More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50230005(TCMDC-125497 | 1-(5-chloro-2-methoxyphenyl)-3-(2-m...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of IGF1R autophosphorylation in human MCF7 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50210252((2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50271906(6-benzyl-N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50271907(2-(2-chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50201141(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed