Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50030502
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297172(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 0.980nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297181(2-[1-(1,3-Benzodioxol-5-ylcarbonyl)piperidin-4-yli...)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297183(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297177(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297182(2-[1-(3,4-Dimethoxybenzoyl)piperidin-4-ylidene]-N-...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297190(2-(1-Benzoylpiperidin-4-ylidene)-N-{(3R)-1-[(6-flu...)
Affinity DataIC50: 4.40nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297188(2-[1-(2-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)...)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297180(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297185(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 5.10nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297179(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 5.10nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297184(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297174(2-[1-(4-Fluoro-2-hydroxybenzoyl)piperidin-4-yliden...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297173(2-[1-(4-Chloro-2-hydroxybenzoyl)piperidin-4-yliden...)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 8.40nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297187((R)-2-(1-(3-fluorobenzoyl)piperidin-4-ylidene)-N-(...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297176(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264142(N-(8-((6-fluoronaphthalen-2-yl)methyl)-8-azabicycl...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297186(2-[1-(4-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264212(N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabi...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297178(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50225349(N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}b...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297175(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297195((2E)-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrol...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297199(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297189(2-(1-Acetylpiperidin-4-ylidene)-N-{(3R)-1-[(6-fluo...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297197(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297192(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProbable C-C chemokine receptor type 3(Mouse)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 230nMAssay Description:Inhibition of mouse CCR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297198(4-Fluoro-N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]-p...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297194(N-({(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297196(N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}-...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297201(N-{(rac)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin...)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297202((rac)-N-{1-[(6-Fluoro-2-naphthyl)methyl]piperidin-...)
Affinity DataIC50: 550nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50225353(4-fluoro-N-{1-[(6-fluoro-2-naphthyl)methyl]piperid...)
Affinity DataIC50: 640nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297191((2E)-3-(1-Benzoylpiperidin-4-yl)-N-{(3R)-1-[(6-flu...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProbable C-C chemokine receptor type 3(Mouse)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264212(N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabi...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mouse CCR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297193(N-({1-[(6-Fluoro-2-naphthyl)methyl]piperidin-4-yl}...)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297200(N-{(3S)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50225356((2E)-N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4...)
Affinity DataIC50: 9.70E+3nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50297171(N-{(3R)-1-[(6-Fluoro-2-naphthyl)methyl]pyrrolidin-...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50264212(N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)methyl]-8-azabi...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed