Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50030766
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: 100nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301062(N-(2-cyclopropylethyl)-6-(4-(2-(trifluoromethyl)be...)
Affinity DataIC50: 300nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: 300nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301061(6-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)py...)
Affinity DataIC50: 700nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301065(2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301056(N-methyl-2-(4-(2-(trifluoromethyl)benzoyl)piperazi...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301060(N-(2-cyclopropyl-2-hydroxyethyl)-6-(4-(2-(trifluor...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301058((4-(thiazol-2-yl)piperazin-1-yl)(2-(trifluoromethy...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301056(N-methyl-2-(4-(2-(trifluoromethyl)benzoyl)piperazi...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301059(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA 6-desaturase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to delta-6 saturase in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301058((4-(thiazol-2-yl)piperazin-1-yl)(2-(trifluoromethy...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301064(N-(2-cyclopropylethyl)-2-(4-(2-(trifluoromethyl)be...)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA (8-3)-desaturase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to delta-5 saturase in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301059(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: 6.80E+4nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Rat)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301063(N-(2-cyclopropylethyl)-2-(4-(2-(trifluoromethyl)be...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed