Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50032048
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKd:  9nMAssay Description:Binding affinity to human cyclophilin 18 assessed as reduction in calcineurin activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323715(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 2.79nMAssay Description:Inhibition of PPIase activity of cyclophilin 18 by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PPIase activity of cyclophilin 18 by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323716(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 4.75nMAssay Description:Inhibition of PPIase activity of cyclophilin 18 by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323712((R,S,S,S,S,S,R,R,S,S,S,S,E)-N,N'-(4,4'-((Z)-diazen...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PPIase activity of cyclophilin 18 by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323716(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 49nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323716(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 75nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 89nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: 100nMAssay Description:Binding affinity to human cyclophilin 18More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 135nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323713((E/Z)-(R,S,S,S,S,S,R,R,S,S,S,S)-N,N'-(4,4'-(diazen...)
Affinity DataIC50: 140nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323715(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 147nMAssay Description:Binding affinity to cyclophilin 18 assessed as reduction in [33P]phosphatase activity of calcineurin by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323713((E/Z)-(R,S,S,S,S,S,R,R,S,S,S,S)-N,N'-(4,4'-(diazen...)
Affinity DataIC50: 206nMAssay Description:Inhibition of PPIase activity of cyclophilin 18 by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323716(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethy...)
Affinity DataIC50: 227nMAssay Description:Binding affinity to streptavidin-coupled biotin-labeled cyclophilin 18 assessed as reduction in [33P] phosphatase activity of calcineurin by protease...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323712((R,S,S,S,S,S,R,R,S,S,S,S,E)-N,N'-(4,4'-((Z)-diazen...)
Affinity DataIC50: 266nMAssay Description:Binding affinity to cyclophilin 18 assessed as reduction in calcineurin activity by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323713((E/Z)-(R,S,S,S,S,S,R,R,S,S,S,S)-N,N'-(4,4'-(diazen...)
Affinity DataIC50: 358nMAssay Description:Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323713((E/Z)-(R,S,S,S,S,S,R,R,S,S,S,S)-N,N'-(4,4'-(diazen...)
Affinity DataIC50: 487nMAssay Description:Binding affinity to cyclophilin 18 assessed as reduction in calcineurin activity by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 950nMAssay Description:Binding affinity to cyclophilin 18 assessed as reduction in [33P]phosphatase activity of calcineurin by protease coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of calcineurin-mediated streptavidin-coupled NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetProtein phosphatase 3 catalytic subunit alpha(Human)
Max Planck Research Unit For Enzymology of Protein Folding

Curated by ChEMBL
LigandPNGBDBM50323714(N-(4-((Z)-(4-(2-(((2R,5S,8S,11S,14S,17S,23S,26S,29...)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of calcineurin-mediated streptavidin-coupled NFAT activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed