Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 3427
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33410(CHEMBL16755 | N-hydroxyisoquinolinedione, 2 | US20...)
Affinity DataIC50: 135nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33419(pyrimidinol carboxylic acid, 11)
Affinity DataIC50: 175nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33411(hydroxytropolone, 3 | β-Thujaplicinol)
Affinity DataIC50: 660nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33418(pyrimidinol carboxylic acid, 10)
Affinity DataIC50: 1.15E+3nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33417(pyrimidinol carboxylic acid, 9)
Affinity DataIC50: 1.45E+3nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33415(CHEMBL204900 | pyrimidinol carboxylic acid, 7)
Affinity DataIC50: 2.50E+3nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33412(CHEMBL183852 | N-hydroxy quinazolinedione, 4 | US1...)
Affinity DataIC50: 6.00E+3nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33409(alpha, gamma-diketo acid, 1)
Affinity DataIC50: 9.85E+3nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33416(pyrimidinol carboxylic acid, 8)
Affinity DataIC50: 1.02E+4nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33414(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Affinity DataIC50: 1.30E+4nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33413(benzo[7]annulene-8-carboxylic acid, 5)
Affinity DataIC50: 2.32E+4nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetRibonuclease H1(Human)
Gilead Sciences

LigandPNGBDBM33419(pyrimidinol carboxylic acid, 11)
Affinity DataIC50: 4.85E+4nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM33420(pyrimidinol carboxylic acid, 12)
Affinity DataIC50: 7.20E+4nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetRibonuclease H1(Human)
Gilead Sciences

LigandPNGBDBM33418(pyrimidinol carboxylic acid, 10)
Affinity DataIC50: 7.40E+4nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetRibonuclease H1(Human)
Gilead Sciences

LigandPNGBDBM33414(CHEMBL440562 | pyrimidinol carboxylic acid, 6)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetRibonuclease H1(Human)
Gilead Sciences

LigandPNGBDBM33415(CHEMBL204900 | pyrimidinol carboxylic acid, 7)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetRibonuclease H1(Human)
Gilead Sciences

LigandPNGBDBM33416(pyrimidinol carboxylic acid, 8)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetRibonuclease H1(Human)
Gilead Sciences

LigandPNGBDBM33417(pyrimidinol carboxylic acid, 9)
Affinity DataIC50: 1.00E+5nMpH: 8.0 T: 2°CAssay Description:Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed