Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50030851
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50087267((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302790((R)-(4-(4-hydroxy-3-methylbenzyl)-8-oxo-2-phenethy...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302787((R)-(4-(4-chlorobenzyl)-8-oxo-2-phenethyl-2,4,5,6,...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302782((R)-(4-benzyl-8-oxo-2-phenethyl-2,4,5,6,7,8-hexahy...)
Affinity DataIC50: 310nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302789((R)-(4-(4-methylbenzyl)-8-oxo-2-phenethyl-2,4,5,6,...)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302786((R)-(4-(4-hydroxy-3-methylbenzyl)-8-oxo-2-phenethy...)
Affinity DataIC50: 740nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302781((R)-(8-oxo-2-phenethyl-2,4,5,6,7,8-hexahydropyrazo...)
Affinity DataIC50: 790nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302788((R)-(4-(4-bromobenzyl)-8-oxo-2-phenethyl-2,4,5,6,7...)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302792((R)-(4-((1-methyl-1H-indol-3-yl)methyl)-8-oxo-2-ph...)
Affinity DataIC50: 1.07E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302785((R)-(4-(4-methylbenzyl)-8-oxo-2-phenethyl-2,4,5,6,...)
Affinity DataIC50: 1.18E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302784((R)-(4-(4-fluorobenzyl)-8-oxo-2-phenethyl-2,4,5,6,...)
Affinity DataIC50: 1.28E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302791((R)-(4-(4-nitrobenzyl)-8-oxo-2-phenethyl-2,4,5,6,7...)
Affinity DataIC50: 1.42E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302783((R)-(4-benzyl-8-oxo-2-phenethyl-2,4,5,6,7,8-hexahy...)
Affinity DataIC50: 1.45E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302779((R)-tert-butyl 4-(2-(6-benzyl-4-(cyclopropanecarbo...)
Affinity DataIC50: 4.31E+3nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50302780((S)-tert-butyl 4-(2-(6-benzyl-4-(cyclopropanecarbo...)
Affinity DataIC50: 1.30E+4nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed