Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50031346
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311657(1-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-p...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311656(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311657(1-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-p...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311644(1-(9-(2,6-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311640(1-(8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311639(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311655(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311642(1-(9-(2,3-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311656(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311644(1-(9-(2,6-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311653((R)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311648((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-fluorochro...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311651((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochro...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311638(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311647((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(5-fluorochro...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311655(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(8-fluoroc...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311637(9-(tetrahydro-2H-pyran-4-yl)-2-(6-(trifluoromethyl...)
Affinity DataIC50: 68nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311643(9-(2,6-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311648((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-fluorochro...)
Affinity DataIC50: 83nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311646((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311650((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(7-fluorochro...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311647((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(5-fluorochro...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311641(9-(2,3-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)
Affinity DataIC50: 108nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311635(2-(1H-benzo[d]imidazol-1-yl)-9-(tetrahydro-2H-pyra...)
Affinity DataIC50: 115nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311652((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-chlorochro...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311646((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(chroman-4-yl...)
Affinity DataIC50: 170nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311645(1-(9-(2,6-dichlorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311636(9-(tetrahydro-2H-pyran-4-yl)-2-(5-(trifluoromethyl...)
Affinity DataIC50: 245nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311650((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(7-fluorochro...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311642(1-(9-(2,3-difluorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50: 270nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311651((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochro...)
Affinity DataIC50: 285nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311643(9-(2,6-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311653((R)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)
Affinity DataIC50: 333nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311649((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-chlorochro...)
Affinity DataIC50: 365nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311639(2-(6-chloro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)
Affinity DataIC50: 393nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311640(1-(8-oxo-9-(tetrahydro-2H-pyran-4-yl)-8,9-dihydro-...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311649((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(6-chlorochro...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311654((S)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human JAK3 (508-1124) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311637(9-(tetrahydro-2H-pyran-4-yl)-2-(6-(trifluoromethyl...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311652((+/-)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-chlorochro...)
Affinity DataIC50: 840nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311641(9-(2,3-difluorobenzyl)-2-(6-fluoro-1H-benzo[d]imid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311645(1-(9-(2,6-dichlorobenzyl)-8-oxo-8,9-dihydro-7H-pur...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311636(9-(tetrahydro-2H-pyran-4-yl)-2-(5-(trifluoromethyl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311635(2-(1H-benzo[d]imidazol-1-yl)-9-(tetrahydro-2H-pyra...)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311638(2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-(tetrahydr...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311654((S)-2-(1H-benzo[d]imidazol-1-yl)-9-(8-fluorochroma...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human JAK2 (532-1132) by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed