Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 3474
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35240(3-(phenylsulfonyl)-1H-indole, 18m)
Affinity DataAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35239(3-(phenylsulfonyl)-1H-indole, 28b)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35238(3-(phenylsulfonyl)-1H-indole, 28a)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35237(3-(phenylsulfonyl)-1H-indole, 26b)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)
Affinity DataAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35236(3-(phenylsulfonyl)-1H-indole, 26a)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35233(3-(phenylsulfonyl)-1H-indole, 27a)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35235(3-(phenylsulfonyl)-1H-indole, 27b)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35255(2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)t...)
Affinity DataKi:  0.5nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataKi:  0.600nM ΔG°:  -54.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35256(MIANSERIN (+) | MIANSERIN | Lerivon | Tolvon | MIA...)
Affinity DataKi:  3nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  4nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM22417(LY 94939 | Nisoxetine Inhibitor | Nisoxetine | LY1...)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35230(indole, 14)
Affinity DataKi:  9nM ΔG°:  -47.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35228(Ludiomil | CHEMBL21731 | Dibencycladine | maprotil...)
Affinity DataKi:  12nM ΔG°:  -47.0kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35252(3-(phenylsulfonyl)-1H-indole, 33b)
Affinity DataKi:  13nM ΔG°:  -46.8kJ/mole IC50: 12nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35245(3-(phenylsulfonyl)-1H-indole, 18g)
Affinity DataKi:  19nM IC50: 31nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35251(3-(phenylsulfonyl)-1H-indole, 33a)
Affinity DataKi:  21nM ΔG°:  -45.6kJ/mole IC50: 29nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35244(3-(phenylsulfonyl)-1H-indole, 18f)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/mole IC50: 51nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)
Affinity DataKi:  27nM ΔG°:  -44.9kJ/mole IC50: 47nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35232(3-(phenylsulfonyl)-1H-indole, 18b)
Affinity DataKi:  28nM ΔG°:  -44.8kJ/mole IC50: 49nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35248(3-(phenylsulfonyl)-1H-indole, 18j)
Affinity DataKi:  33nM IC50: 69nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35231(3-(phenylsulfonyl)-1H-indole, 18a)
Affinity DataKi:  45nM ΔG°:  -43.6kJ/mole IC50: 80nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35250(3-(phenylsulfonyl)-1H-indole, 18l)
Affinity DataKi:  46nM IC50: 57nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)
Affinity DataKi:  59nM IC50: 180nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35246(3-(phenylsulfonyl)-1H-indole, 18h)
Affinity DataKi:  73nM ΔG°:  -42.4kJ/mole IC50: 128nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35242(3-(phenylsulfonyl)-1H-indole, 18d)
Affinity DataKi:  78nM ΔG°:  -42.2kJ/mole IC50: 146nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35249(3-(phenylsulfonyl)-1H-indole, 18k)
Affinity DataKi:  89nM IC50: 92nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35244(3-(phenylsulfonyl)-1H-indole, 18f)
Affinity DataKi:  110nM IC50: 650nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35246(3-(phenylsulfonyl)-1H-indole, 18h)
Affinity DataKi:  117nM IC50: 258nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35249(3-(phenylsulfonyl)-1H-indole, 18k)
Affinity DataKi:  125nM ΔG°:  -41.0kJ/mole IC50: 116nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35248(3-(phenylsulfonyl)-1H-indole, 18j)
Affinity DataKi:  208nM ΔG°:  -39.7kJ/mole IC50: 221nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35232(3-(phenylsulfonyl)-1H-indole, 18b)
Affinity DataKi:  222nM IC50: 832nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35231(3-(phenylsulfonyl)-1H-indole, 18a)
Affinity DataKi:  262nM IC50: 459nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35241(3-(phenylsulfonyl)-1H-indole, 18c)
Affinity DataKi:  273nM IC50: 1.11E+3nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35241(3-(phenylsulfonyl)-1H-indole, 18c)
Affinity DataKi:  306nM ΔG°:  -38.7kJ/mole IC50: 353nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35243(3-(phenylsulfonyl)-1H-indole, 18e)
Affinity DataKi:  367nM IC50: 1.08E+3nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35242(3-(phenylsulfonyl)-1H-indole, 18d)
Affinity DataKi:  389nM IC50: 1.03E+3nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35245(3-(phenylsulfonyl)-1H-indole, 18g)
Affinity DataKi:  428nM ΔG°:  -37.8kJ/mole IC50: 460nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)
Affinity DataKi:  434nMAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35243(3-(phenylsulfonyl)-1H-indole, 18e)
Affinity DataKi:  487nM ΔG°:  -37.5kJ/mole IC50: 302nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35252(3-(phenylsulfonyl)-1H-indole, 33b)
Affinity DataKi:  619nM IC50: 5.98E+3nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35251(3-(phenylsulfonyl)-1H-indole, 33a)
Affinity DataKi:  713nM IC50: 477nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35240(3-(phenylsulfonyl)-1H-indole, 18m)
Affinity DataKi:  792nM ΔG°:  -36.2kJ/mole IC50: 960nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

LigandPNGBDBM35253(3-(phenylsulfonyl)-1H-indole, 33c)
Affinity DataKi:  854nM IC50: 7.97E+3nMAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35253(3-(phenylsulfonyl)-1H-indole, 33c)
Affinity DataKi:  1.03E+3nM ΔG°:  -35.5kJ/mole IC50: 707nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandPNGBDBM35250(3-(phenylsulfonyl)-1H-indole, 18l)
Affinity DataKi:  1.13E+3nM ΔG°:  -35.3kJ/mole IC50: 1.09E+3nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)
Affinity DataKi:  2.40E+3nMAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed