Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50041757
TargetG-protein coupled bile acid receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataEC50:  31.6nMAssay Description:Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataEC50:  631nMAssay Description:Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414956(CHEMBL583110)
Affinity DataEC50:  5.01E+3nMAssay Description:Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataEC50:  79.4nMAssay Description:Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataEC50:  501nMAssay Description:Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataEC50:  158nMAssay Description:Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataIC50: 316nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataIC50: 316nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414955(CHEMBL576138)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414954(CHEMBL575966)
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed