Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50031487
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4-kinase beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to PIK4CbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  780nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  160nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetActivin receptor type-2B(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  92nMAssay Description:Binding affinity to ACVR2betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  17nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dim...)
Affinity DataKd:  15nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dim...)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  260nMAssay Description:Binding affinity to CSNK1epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  190nMAssay Description:Binding affinity to JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  170nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  19nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  16nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  120nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314072(5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM15244(cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314073(3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-...)
Affinity DataKi:  5.80nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50418610(GW-856553 | GW856553X | LOSMAPIMOD | US10550073, C...)
Affinity DataKi:  25nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed