Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50031043
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305827(4-((3-(2-(3-methoxybenzyl)-2H-tetrazol-5-yl)benzam...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant MMP13 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305828(4-((3-(2-(4-methoxybenzyl)-2H-tetrazol-5-yl)benzam...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant MMP13 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305826(4-((3-(3-methoxybenzylcarbamoyl)benzamido)methyl)b...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant MMP13 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305828(4-((3-(2-(4-methoxybenzyl)-2H-tetrazol-5-yl)benzam...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305827(4-((3-(2-(3-methoxybenzyl)-2H-tetrazol-5-yl)benzam...)
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305826(4-((3-(3-methoxybenzylcarbamoyl)benzamido)methyl)b...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305841(N1,N3-bis(3-methoxybenzyl)isophthalamide | CHEMBL6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305851(trans-4-((5-(2-(3-methoxybenzylcarbamoyl)-6-methyl...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305844(4-((5-(2-(3-methoxybenzylcarbamoyl)-6-methylpyridi...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305858(trans-4-((5-(2-(4-fluoro-3-methylbenzylcarbamoyl)-...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305856(trans-4-((5-(2-(3-chloro-4-fluorobenzylcarbamoyl)-...)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305855(trans-4-((5-(2-(4-fluoro-3-methoxybenzylcarbamoyl)...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305857(trans-4-((5-(2-(4-fluoro-3-(trifluoromethyl)benzyl...)
Affinity DataKi:  0.620nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305854(trans-4-((5-(2-(4-fluoro-3-hydroxybenzylcarbamoyl)...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305850(trans-4-((5-(2-(3-hydroxybenzylcarbamoyl)-6-methyl...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305852(trans-4-((5-(2-(3-isopropoxybenzylcarbamoyl)-6-met...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305833(4-((5-(2-(3-methoxybenzylcarbamoyl)pyridin-4-yl)-2...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305845(4-((5-(2-methyl-6-(3-(trifluoromethyl)benzylcarbam...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305840(4-((5-(2-(3,4-difluorobenzylcarbamoyl)-6-methylpyr...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305847(trans-4-((5-(2-(4-methoxybenzylcarbamoyl)-6-methyl...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305843(4-((5-(2-(4-methoxybenzylcarbamoyl)-6-methylpyridi...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305838(4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylpyridin...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305849(trans-4-((5-(2-(3-cyanobenzylcarbamoyl)-6-methylpy...)
Affinity DataKi:  6.70nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305853(trans-4-((5-(2-(3,4-difluorobenzylcarbamoyl)-6-met...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305836(4-((5-(2-(3-(trifluoromethyl)benzylcarbamoyl)pyrid...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305835(4-((5-(2-(3-chlorobenzylcarbamoyl)pyridin-4-yl)-2H...)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305837(4-((5-(2-(benzylcarbamoyl)-6-methylpyridin-4-yl)-2...)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305848(trans-4-((5-(2-(3-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305839(4-((5-(2-(3-fluorobenzylcarbamoyl)-6-methylpyridin...)
Affinity DataKi:  29nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305846(trans-4-((5-(2-(benzylcarbamoyl)-6-methylpyridin-4...)
Affinity DataKi:  31nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305832(4-((5-(2-(4-methoxybenzylcarbamoyl)pyridin-4-yl)-2...)
Affinity DataKi:  37nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305831(4-((5-(2-(3,4-difluorobenzylcarbamoyl)pyridin-4-yl...)
Affinity DataKi:  43nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305829(4-((5-(2-(4-fluorobenzylcarbamoyl)pyridin-4-yl)-2H...)
Affinity DataKi:  65nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305830(4-((5-(2-(3-fluorobenzylcarbamoyl)pyridin-4-yl)-2H...)
Affinity DataKi:  76nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305834(4-((5-(2-(4-chlorobenzylcarbamoyl)pyridin-4-yl)-2H...)
Affinity DataKi:  227nMAssay Description:Inhibition of human recombinant full length MMP13 assessed as type 3 collagen cleavage activity after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-25(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP25More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-26(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP26More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-24(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP24More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-16(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP16More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-15(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP15More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMatrilysin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305842(trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylp...)
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
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