Compile Data Set for Download or QSAR
Report error Found 83 Enz. Inhib. hit(s) with all data for entry = 50004324
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in total Abeta level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataEC50:  126nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28944((2S)-2-hydroxy-3-methyl-N-[(1S)-1-{[(1S)-3-methyl-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as effect on Abeta40 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481776(CHEMBL597830)
Affinity DataIC50: 251nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481781(CHEMBL599561)
Affinity DataIC50: 316nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481777(CHEMBL597226)
Affinity DataIC50: 316nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481783(CHEMBL597305)
Affinity DataIC50: 398nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481794(CHEMBL599734)
Affinity DataIC50: 398nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481785(CHEMBL606205)
Affinity DataIC50: 398nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481777(CHEMBL597226)
Affinity DataEC50:  501nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481790(CHEMBL599683)
Affinity DataEC50:  501nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481790(CHEMBL599683)
Affinity DataIC50: 501nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481774(CHEMBL598450)
Affinity DataIC50: 631nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481775(CHEMBL597829)
Affinity DataIC50: 631nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481795(CHEMBL606170)
Affinity DataIC50: 631nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481782(CHEMBL597302)
Affinity DataIC50: 794nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481796(CHEMBL597705)
Affinity DataIC50: 794nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481777(CHEMBL597226)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481787(CHEMBL604928)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481790(CHEMBL599683)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481791(CHEMBL598707)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481774(CHEMBL598450)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481779(CHEMBL591008)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481773(CHEMBL597884)
Affinity DataEC50:  1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481793(CHEMBL605147)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481784(CHEMBL600684)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481788(CHEMBL597831)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481773(CHEMBL597884)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481792(CHEMBL599538)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481780(CHEMBL599539)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481774(CHEMBL598450)
Affinity DataEC50:  3.16E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481776(CHEMBL597830)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481773(CHEMBL597884)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481797(CHEMBL599146)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481787(CHEMBL604928)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481773(CHEMBL597884)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481777(CHEMBL597226)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataEC50:  7.94E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481788(CHEMBL597831)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481791(CHEMBL598707)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481791(CHEMBL598707)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481792(CHEMBL599538)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481778(CHEMBL603905)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481787(CHEMBL604928)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481786(CHEMBL598504)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
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