Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50031430
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313152((3R,5S)-5-((R)-2-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)...)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 3 nM 1,25-(OH)2D3-induced transcriptional activa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313152((3R,5S)-5-((R)-2-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)...)
Affinity DataIC50: 3.30E+3nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 300 nM 1,25-(OH)2D3-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313153((S)-tert-butyl 2-(2,7-diisobutyl-4-isopentyl-3-oxo...)
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 3 nM 1,25-(OH)2D3-induced transcriptional activa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonist activity at human recombinant ERbeta LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50: 2.30E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 300 nM 1,25-(OH)2D3-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313154((S)-8-(2-aminoethylamino)-2,7-diisobutyl-4-isopent...)
Affinity DataIC50: 2.80E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 300 nM 1,25-(OH)2D3-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313156((S)-1-(2,7-diisobutyl-4-isopentyl-3-oxo-2,3,4,5-te...)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313155((S)-N-(2-(2,7-diisobutyl-4-isopentyl-3-oxo-2,3,4,5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313151((S)-8-amino-2-isobutyl-4-isopentyl-7-(2-methylprop...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant ERalpha LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant ERalpha LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant ERbeta LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 3 nM 1,25-(OH)2D3-induced transcriptional activa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50253371(N4-Isobutyl-6-(2-naphthalen-1-yl-ethyl)-N2-naphtha...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of ARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313149(6-(2-benzylpyridin-4-yl)-3-hydroxy-5-isobutyl-1-(n...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of ERMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313148(N2,N4,6-triisobutylpyrimidine-2,4-diamine | CHEMBL...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibition of ERMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed