Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50022601
TargetCentromere protein E(Canis lupus familiaris)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to wild-type dog CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere protein E(Canis lupus familiaris)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to wild-type dog CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  3.10nMAssay Description:Uncompetitive binding affinity to microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  3.20nMAssay Description:Uncompetitive binding affinity to C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to wild-type human CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653004(CHEMBL5712053)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to wild-type human CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653004(CHEMBL5712053)
Affinity DataKi:  4.20nMAssay Description:Uncompetitive-like binding affinity to C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653004(CHEMBL5712053)
Affinity DataKi:  4.70nMAssay Description:Uncompetitive binding affinity to microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human CENP-E K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  13nMAssay Description:Binding affinity to human CENP-E T183A mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human CENP-E I182L mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  18nMAssay Description:Binding affinity to human CENP-E I182L/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  61nMAssay Description:Binding affinity to human CENP-E I182L/T183A mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  64nMAssay Description:Binding affinity to human CENP-E I182L/T183A/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Mus musculus)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataKi:  67nMAssay Description:Binding affinity to wild-type mouse CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  73nMAssay Description:Binding affinity to human CENP-E I182L/T183A/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Mus musculus)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  89nMAssay Description:Binding affinity to wild-type mouse CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataIC50: 550nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50652774(Gsk-923295a | Gsk923295 | GSK-295 | GSK-923295 | G...)
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653003(CHEMBL5712065)
Affinity DataKi:  4.40E+3nMAssay Description:Competitive-like binding affinity to C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) asses...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCentromere-associated protein E(Human)
Cytokinetics Inc

Curated by ChEMBL
LigandPNGBDBM50653004(CHEMBL5712053)
Affinity DataIC50: 7.37E+3nMAssay Description:Inhibition of ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed