Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50031465
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313798(N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-h...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 25nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313796((2R,4S,5S)-5-((S)-2-((S)-2-acetamidopropanamido)-4...)
Affinity DataIC50: 35nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313797((2R,4S,5S)-5-((S)-2-((S)-2-acetamido-3-methylbutan...)
Affinity DataIC50: 48nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313798(N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-h...)
Affinity DataIC50: 53nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 67nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-transfected with human APP assessed as inhibition of cellular release of Abeta 40 after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 120nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM16077((2R,4S,5S)-N-butyl-5-[(2S)-2-[(2S)-2-acetamido-4-m...)
Affinity DataIC50: 120nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 130nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-transfected with human APP assessed as inhibition of cellular release of Abeta 40 after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313806((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 140nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 150nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313799((1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,...)
Affinity DataIC50: 150nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313799((1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,...)
Affinity DataIC50: 170nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313801((1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 200nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313800((1R,3S)-3-[1-(acetylamino)-1-methylethyl]-N-[(1S,2...)
Affinity DataIC50: 240nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM16077((2R,4S,5S)-N-butyl-5-[(2S)-2-[(2S)-2-acetamido-4-m...)
Affinity DataIC50: 260nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313800((1R,3S)-3-[1-(acetylamino)-1-methylethyl]-N-[(1S,2...)
Affinity DataIC50: 370nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313797((2R,4S,5S)-5-((S)-2-((S)-2-acetamido-3-methylbutan...)
Affinity DataIC50: 370nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 410nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 560nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313803((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 580nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313804((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 660nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-transfected with human APP assessed as inhibition of cellular release of Abeta 40 after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313799((1R,3S)-3-((S)-1-acetamido-2-methylpropyl)-N-((2S,...)
Affinity DataIC50: 800nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313805((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 960nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313801((1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313801((1R,3S)-3-(1-acetamidocyclopentyl)-N-((2S,3S,5R)-6...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313800((1R,3S)-3-[1-(acetylamino)-1-methylethyl]-N-[(1S,2...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313803((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313802((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hy...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313796((2R,4S,5S)-5-((S)-2-((S)-2-acetamidopropanamido)-4...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313802((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hy...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313803((1R,3S)-N-((2S,3S)-3-hydroxy-4-(3-isopropylbenzyla...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Montreal

Curated by ChEMBL
LigandPNGBDBM50313802((1R,3S)-3-(2-acetamidopropan-2-yl)-N-((2S,3S)-3-hy...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of Cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed