Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50031529
LigandPNGBDBM50314789(N-cyclopropyl-3-(1-(2-fluorophenyl)phthalazin-6-yl...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to c-Kit by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314789(N-cyclopropyl-3-(1-(2-fluorophenyl)phthalazin-6-yl...)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.310nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314790(N-Cyclopropyl-3-(1-(2-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataKd:  0.180nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314789(N-cyclopropyl-3-(1-(2-fluorophenyl)phthalazin-6-yl...)
Affinity DataKd:  320nMAssay Description:Binding affinity to Kdr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Kdr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314790(N-Cyclopropyl-3-(1-(2-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Kdr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314789(N-cyclopropyl-3-(1-(2-fluorophenyl)phthalazin-6-yl...)
Affinity DataKd:  530nMAssay Description:Binding affinity to Lck by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Lck by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314790(N-Cyclopropyl-3-(1-(2-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Lck by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to c-Kit by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314790(N-Cyclopropyl-3-(1-(2-fluorophenyl)-7-methyl-6-oxo...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to c-Kit by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to RAF1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKd:  0.670nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314784(4-Chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataIC50: 7nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314782(N-Cyclopropyl-3-(1-(2,4-difluorophenyl)-7-ethyl-6-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314782(N-Cyclopropyl-3-(1-(2,4-difluorophenyl)-7-ethyl-6-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314785(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314778(3-(1-(2-Chlorophenyl)-7-methyl-6-oxo-6,7-dihydro-1...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314788(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314784(4-Chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314786(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314787(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314777(N-Cyclopropyl-4-methyl-3-(7-methyl-6-oxo-1-o-tolyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314781(N-Cyclopropyl-3-(1-(2,5-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314792(1-(2,6-Difluorophenyl)-7-methyl-5-(6-methyl-3-(met...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314779(N-Cyclopropyl-4-methyl-3-(7-methyl-6-oxo-1-(3-(tri...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314783(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-3,7-dimeth...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314791(3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  458nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of p38-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed