Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 50031774
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 in human NCI-H1975 cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318878((S)-3-(3-methoxy-4-(4-(1,4,5,6-tetrahydropyrimidin...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50162757((3S,7S)-7-Hydroxy-3-(6-methoxy-pyridin-3-yl)-9-(5,...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318885(teriparatide | CHEMBL525610)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50177628((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(3-(5,6,7,8-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50201116(3-(3-pyridyl)-3-[4-[2-(5,6,7,8-tetrahydro[1,8]naph...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to cannabinoid CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50235980(CHEMBL429876 | EMD-121974 | cyclo(Arg-Gly-Asp-D-Ph...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50253098((1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity to cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50101858(4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to mouse EP4 receptor by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM35847(DINOPROSTONE | [3H]Prostaglandin E2 | prostaglandi...)
Affinity DataIC50: 0.940nMAssay Description:Binding affinity to EP3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318885(teriparatide | CHEMBL525610)
Affinity DataEC50:  1nMAssay Description:Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM35847(DINOPROSTONE | [3H]Prostaglandin E2 | prostaglandi...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50150698(3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM19855(N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-(4-propyl...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFocal adhesion kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318871(methyl 4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydro...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318881(N-(1-((2S,3S)-2-ethyl-4-oxotetrahydrofuran-3-ylcar...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50180036(CHEMBL371214 | (6aR,10aR)-3-(1,1-dimethylbutyl)-6a...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318880((S)-2-(4-(2-(1-(biphenyl-3-ylamino)cyclohexanecarb...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318880((S)-2-(4-(2-(1-(biphenyl-3-ylamino)cyclohexanecarb...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318882(4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)-N-(1-((...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50181298(5-(3-((S)-2-((R)-3-hydroxy-4-(3-(trifluoromethyl)p...)
Affinity DataIC50: 6nMAssay Description:Binding affinity to rat EP4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM21279(N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iod...)
Affinity DataKi:  7.49nMAssay Description:Binding affinity to cannabinoid CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM35847(DINOPROSTONE | [3H]Prostaglandin E2 | prostaglandi...)
Affinity DataIC50: 9.90nMAssay Description:Binding affinity to EP4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318879(N-[1-((S)-(S)-4-Benzoyl-6-(S)-oxo-hexahydro-pyrrol...)
Affinity DataKi:  10.1nMAssay Description:Inhibition of cathepsin K at enzyme-substrate complex stateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318884(CHEMBL1084546 | CHEMBL2430359 | N-methyl-N-(3-((2-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50249410(5-amino-4-(isobutylamino)-6-morpholinopyrimidine-2...)
Affinity DataIC50: 18nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50265621(HU-308 | ((1R,4S,5R)-4-(2,6-dimethoxy-4-(2-methylo...)
Affinity DataKi:  22.7nMAssay Description:Binding affinity to cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318873((1S,2S,3R,4R,5S)-6-{2-[(1R)-1-[(2R)-3-{[1-(3-fluor...)
Affinity DataIC50: 25nMAssay Description:Inhibition of CaSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50160434(AM630 | (6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-...)
Affinity DataKi:  31.2nMAssay Description:Binding affinity to cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50100971(N-(3,5-dichlorophenyl)imidodicarbonimidic diamide ...)
Affinity DataIC50: 33.5nMAssay Description:Inhibition of integrin alpha-V-beta-3-mediated adhesion of human cells M21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318883(VEL-0230 | sodium(2S,3S)-3-((S)-1-isobutoxy-4-meth...)
Affinity DataIC50: 34.5nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM35847(DINOPROSTONE | [3H]Prostaglandin E2 | prostaglandi...)
Affinity DataIC50: 37.7nMAssay Description:Binding affinity to EP2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Bovine)
Amgen

Curated by ChEMBL
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataEC50:  41nMAssay Description:Inhibition of CaSR in bovine parathyroid cells assessed as increase in PTH levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human CaSR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318871(methyl 4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydro...)
Affinity DataKi:  56nMAssay Description:Binding affinity to mouse EP3 receptor by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318880((S)-2-(4-(2-(1-(biphenyl-3-ylamino)cyclohexanecarb...)
Affinity DataIC50: 58nMAssay Description:Inhibition of rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318870(2,6,9-Trisubstituted Purine, AP23451 | 2,6,9-Trisu...)
Affinity DataIC50: 68nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318870(2,6,9-Trisubstituted Purine, AP23451 | 2,6,9-Trisu...)
Affinity DataIC50: 68nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
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