Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50031591
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as stimulation of ERK1/2 phosphorylation in presence of 10 uM alloste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as stimulation of ERK1/2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting in presence of 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells at high affinity site by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315861(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting in presence of 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315861(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  89nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as stimulation of ERK1/2 phosphorylation in presence of 10 uM alloste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315861(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  114nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataEC50:  123nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315861(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  156nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as stimulation of ERK1/2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315855(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  181nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting in presence of 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315861(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315859(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  268nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315861(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  273nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315862(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  288nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315860(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  313nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315853(6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrahy...)
Affinity DataKi:  347nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315855(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  390nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315859(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  417nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315862(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  419nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315853(6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrahy...)
Affinity DataKi:  450nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315854(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  457nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315858(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  469nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315860(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  618nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315855(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  651nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315855(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  661nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315855(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  691nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as stimulation of ERK1/2 phosphorylation in presence of 10 uM alloste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315858(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  741nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315854(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  776nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataKi:  832nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315855(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataEC50:  955nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as stimulation of ERK1/2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315856(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315856(N6-[2-Amino-3-(3,4-dichlorobenzoyl)-4,5,6,7-tetrah...)
Affinity DataKi:  1.36E+3nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells by scintillation counting in presence of 10 uM allosteric modulator ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-amino-4,5-dimethylthien-3-yl)-[3-(trifluorometh...)
Affinity DataEC50:  1.74E+3nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315857((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-methoxyphe...)
Affinity DataKi:  1.86E+3nMAssay Description:Displacement of [3H]DPCX from human adenosine A1 receptor expressed in CHO cells at low affinity site by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315864(2-Amino-6-[3-(4-nitrophenoxy)-propyl]-4,5,6,7-tetr...)
Affinity DataEC50:  3.70E+3nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315863(2-Amino-6-[5-(4-nitrophenoxy)-pentyl]-4,5,6,7-tetr...)
Affinity DataEC50:  5.20E+3nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50315865(2-Amino-6-[2-(4-nitrophenoxy)-ethyl]-4,5,6,7-tetra...)
Affinity DataEC50:  8.50E+3nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed