Compile Data Set for Download or QSAR
Report error Found 151 Enz. Inhib. hit(s) with all data for entry = 50039157
LigandPNGBDBM50327667(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Methy...)
Affinity DataEC50:  0.0603nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327675(Dibenzo[b,f][1,4]oxazepine-4-carboxylic Acid Amide...)
Affinity DataEC50:  0.0759nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327658(11H-Dibenzo[b,e]-azepine-10-carboxylic Acid Methyl...)
Affinity DataEC50:  0.100nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327676(Dibenzo[b,f][1,4]oxazepine-6-carboxylic acid amide...)
Affinity DataEC50:  0.115nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50415923(CHEMBL1084098)
Affinity DataEC50:  0.117nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318511(dibenzo[b,f][1,4]oxazepine | CHEMBL1085100)
Affinity DataEC50:  0.302nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327661(11H-dibenzo[b,e]azepine-2-carboxylic acid methyl e...)
Affinity DataEC50:  0.575nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327660(11H-Dibenzo[b,e]azepine-1-carboxylic acid methyl e...)
Affinity DataEC50:  0.575nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327659(11H-dibenzo[b,e]azepine | morphanthridine | CHEMBL...)
Affinity DataEC50:  3.02nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318461(4-methyl-N-(2,2,2-trichloro-1-(4-chlorophenylthio)...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327678(CHEMBL1258323 | CHEMBL1084638 | 11H-dibenzo[b,e]az...)
Affinity DataEC50:  8.51nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318515(bromo benzyl cyanide | CHEMBL1085832)
Affinity DataEC50:  10nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318460(S-2,2,2-trichloro-1-(4-chlorobenzamido)ethyl ethan...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318458(AMG-7160 | 4-bromo-N-(2,2,2-trichloro-1-(4-chlorop...)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318457(AMG-2504 | 4-nitro-N-(2,2,2-trichloro-1-(4-chlorop...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318514(ethyl bromo acetate | CHEMBL1085948)
Affinity DataEC50:  39nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318458(AMG-7160 | 4-bromo-N-(2,2,2-trichloro-1-(4-chlorop...)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50327666(Dibenzo[b,f][1,4]oxazepine-3-carboxylic acid methy...)
Affinity DataEC50:  52.5nMAssay Description:Activation of human TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318479((1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-oc...)
Affinity DataEC50:  59nMAssay Description:Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318486(CHEMBL422704 | 2-Methyl-2-(4-methyl-pent-3-enyl)-7...)
Affinity DataEC50:  60nMAssay Description:Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  60nMAssay Description:Activation of TRPM8 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataEC50:  66nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataIC50: 91nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318484(CHEMBL190461 | 2-((1R,6R)-6-Isopropenyl-3-methyl-c...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50203073(3-(2-oxopropylidene)-1-(prop-2-ynyl)indolin-2-one ...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in membrane currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318457(AMG-2504 | 4-nitro-N-(2,2,2-trichloro-1-(4-chlorop...)
Affinity DataIC50: 105nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataEC50:  115nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318480(Miogatrial | CHEMBL1085849)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318457(AMG-2504 | 4-nitro-N-(2,2,2-trichloro-1-(4-chlorop...)
Affinity DataIC50: 167nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318478(miogadial | CHEMBL1084611)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM60994((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Affinity DataEC50:  230nMAssay Description:Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318483(Tetrahydrocannabinol acid | CHEMBL1086558)
Affinity DataEC50:  240nMAssay Description:Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318467(N-(4-(3,4-dichlorophenyl)thiazol-2-yl)-2-(2-methyl...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318468(N-(4-(4-chloro-3-methylphenyl)thiazol-2-yl)-2-(2-m...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318469(N-(4-(3,5-difluoro-4-(trifluoromethyl)phenyl)thiaz...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318458(AMG-7160 | 4-bromo-N-(2,2,2-trichloro-1-(4-chlorop...)
Affinity DataIC50: 252nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50240520(benzyl isothiocyanate | BITC, 17 | Isothiocyanic a...)
Affinity DataEC50:  319nMAssay Description:Activation of TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of trinitrophenol-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataEC50:  400nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318454(Diallyl trisulfide | diallyltrisulfane | CHEMBL123...)
Affinity DataEC50:  490nMAssay Description:Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318465(N-(4-(4-chlorophenyl)thiazol-2-yl)-2-(2-methyl-1,3...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318466(2-(2-methyl-1,3-dioxoisoindolin-4-yl)-N-(4-(3-(tri...)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50367298(Cardene | NICARDIPINE)
Affinity DataEC50:  500nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318502(2-(1-(cyclopentylmethyl)-7-fluoro-2-oxoindolin-3-y...)
Affinity DataEC50:  510nMAssay Description:Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in membrane currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
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