Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50032288
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataIC50: 0.180nMAssay Description:Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50243173(N-(2-Benzoyl-phenyl)-4-[3-(3-piperidin-1-yl-propyl...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rabbit)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of rabbit bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326710(7-chloro-2-(3-(9-(pyridin-4-yl)-3,9-diazaspiro[5.5...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326708(N-(4-(4,5-dihydro-1H-imidazol-2-yl)benzyl)-2-(2-(4...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50243301(Tetrahydrofuran-2-ylmethyl 4-{[(2-benzoylphenyl)am...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity to rat bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of rat bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50222658(4-bromo-5-[(2-chlorobenzoyl)amino]-N-[2-[1-(4-pyri...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Mouse)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50326708(N-(4-(4,5-dihydro-1H-imidazol-2-yl)benzyl)-2-(2-(4...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity to mouse bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rhesus macaque)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50151891({2-(2,2-Diphenyl-ethylamino)-5-[4-(4-methyl-pipera...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to monkey bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50151891({2-(2,2-Diphenyl-ethylamino)-5-[4-(4-methyl-pipera...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50254456(N-(2-chlorobenzyl)-2-(N-(4-isobutoxy-3-methoxybenz...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Dog)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataIC50: 16.3nMAssay Description:Antagonist activity at dog bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50151891({2-(2,2-Diphenyl-ethylamino)-5-[4-(4-methyl-pipera...)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50254456(N-(2-chlorobenzyl)-2-(N-(4-isobutoxy-3-methoxybenz...)
Affinity DataKi:  37nMAssay Description:Binding affinity to human bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50243673(N-[4-(2-Benzoyl-phenylsulfamoyl)-phenyl]-acetamide...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50156455((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Affinity DataIC50: 164nMAssay Description:Inhibition of rat bradykinin B1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed