Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50031726
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318022(uridine diphosphate trisodium salt | CHEMBL1096401)
Affinity DataEC50:  1.14E+3nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50306710(CHEMBL1094759 | CHEMBL590494 | ((2R,3S,4R,5R)-3,4-...)
Affinity DataEC50:  945nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318024(((2R,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-puri...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318025(((2R,3S,4R,5R)-5-(6-chloro-4-(methylamino)-1H-imid...)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318026(((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318027(((2R,3S,4R,5R)-5-(6-amino-2-(phenylethynyl)-9H-pur...)
Affinity DataEC50:  0.0360nMAssay Description:Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318031(cangrelor | CHEMBL1097279)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318031(cangrelor | CHEMBL1097279)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at P2Y12 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50: 112nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318029(diammonium (2R,3S,5R)-2-[(hydrogen phosphonatooxy)...)
Affinity DataIC50: 508nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318029(diammonium (2R,3S,5R)-2-[(hydrogen phosphonatooxy)...)
Affinity DataIC50: 508nMAssay Description:Antagonist activity at P2Y1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM50318028(diammonium (2R,3S,5R)-5-(6-amino-2-chloro-9H-purin...)
Affinity DataIC50: 582nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed