Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50031933
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataIC50: 97nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321738(2-Amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(3-thi...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant histidine-tagged ABL (230-517) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321739(2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321746(2-(benzylthio)-4-(thiophen-2-yl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321738(2-Amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(3-thi...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant histidine-tagged ALK (103-1459) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321746(2-(benzylthio)-4-(thiophen-2-yl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant histidine-tagged ALK (103-1459) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321729(2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)-5,...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321738(2-Amino-6-[(2-oxo-2-phenylethyl)sulfanyl]-4-(3-thi...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321740(2-Amino-6-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfany...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321743(2-Amino-6-({2-oxo-2-[4-(trifluoromethyl)phenyl]eth...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321745(2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-t...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant histidine-tagged ALK (103-1459) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321745(2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-t...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321741(2-Amino-6-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321727(2-(Benzylsulfanyl)-4-(3-thienyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321734(2-Amino-6-[(4-chlorobenzyl)sulfanyl]-4-(3-thienyl)...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321730(2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-t...)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321737(2-Amino-6-[(3,4-dichlorobenzyl)sulfanyl]-4-(3-thie...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321739(2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of human recombinant histidine-tagged ALK (103-1459) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321728(2-[(4-Chlorobenzyl)sulfanyl]-4-(3-thienyl)-5,6,7,8...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321736(2-Amino-6-[(4-methylbenzyl)sulfanyl]-4-(3-thienyl)...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321735(2-Amino-6-[(4-methoxybenzyl)sulfanyl]-4-(3-thienyl...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321731(N-(4-Chlorophenyl)-2-{[3-cyano-4-(3-thienyl)-5,6,7...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321733(2-Amino-6-(benzylsulfanyl)-4-(3-thienyl)pyridine-3...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321744(2-Amino-6-{[2-(3-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321732(2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-6-meth...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321729(2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)-5,...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human recombinant histidine-tagged ALK (103-1459) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321742(2-Amino-6-{[2-(4-cyanophenyl)-2-oxoethyl]sulfanyl}...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of human recombinant histidine-tagged RET (700-1020) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321739(2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human recombinant histidine-tagged ABL (230-517) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321746(2-(benzylthio)-4-(thiophen-2-yl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of human recombinant histidine-tagged ABL (230-517) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321745(2-(4-fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-t...)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of human recombinant histidine-tagged ABL (230-517) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM50321729(2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)-5,...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human recombinant histidine-tagged ABL (230-517) expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed