Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50031807
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 10.1nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319660(CHEMBL1085840 | CHEMBL1085838 | (S)-2-((1S,2S,4R)-...)
Affinity DataKi:  12.2nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319664((R,S)-2-((+/-)-exo-Bicyclo[2.2.1]heptan-2-ylamino)...)
Affinity DataIC50: 12.6nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataKi:  12.8nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319660(CHEMBL1085840 | CHEMBL1085838 | (S)-2-((1S,2S,4R)-...)
Affinity DataIC50: 15.3nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319664((R,S)-2-((+/-)-exo-Bicyclo[2.2.1]heptan-2-ylamino)...)
Affinity DataKi:  17.3nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319666((S)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Affinity DataKi:  27.8nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319666((S)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Affinity DataIC50: 28.6nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319667((R)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Affinity DataKi:  30.6nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319668((R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Affinity DataKi:  47.2nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319667((R)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Affinity DataIC50: 56.8nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319659(2-(bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthia...)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319668((R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Affinity DataIC50: 62nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319661(CHEMBL1085105 | CHEMBL1085839 | (R)-2-((1R,2R,4S)-...)
Affinity DataKi:  227nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319660(CHEMBL1085840 | CHEMBL1085838 | (S)-2-((1S,2S,4R)-...)
Affinity DataKi:  329nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319661(CHEMBL1085105 | CHEMBL1085839 | (R)-2-((1R,2R,4S)-...)
Affinity DataKi:  770nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319660(CHEMBL1085840 | CHEMBL1085838 | (S)-2-((1S,2S,4R)-...)
Affinity DataIC50: 885nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319661(CHEMBL1085105 | CHEMBL1085839 | (R)-2-((1R,2R,4S)-...)
Affinity DataIC50: 931nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319661(CHEMBL1085105 | CHEMBL1085839 | (R)-2-((1R,2R,4S)-...)
Affinity DataIC50: 1.51E+3nMAssay Description:Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50319665(AMG-221 | (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed