Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50039174
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319728(rac-4-(3-bromophenyl)-N-(7-chloro-1-oxo-1,2-dihydr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319713(rac-4-(4-bromophenyl)-N-(7-chloro-1-oxo-1,2-dihydr...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319707(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319729(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319717(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319730(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319714(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319726(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319727(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319731(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319733(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319708(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 8nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319710(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 8nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319712(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319715((3R,4S)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319732(rac-4-(3-tert-butylphenyl)-N-(7-chloro-1-oxo-1,2-d...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319634(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 14nMAssay Description:Inhibition of PRKCL2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319709(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319719(2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 15nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 24nMAssay Description:Inhibition of PRKG2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319711(rac-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 26nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319721(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)pipe...)
Affinity DataIC50: 28nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319720(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-1-m...)
Affinity DataIC50: 31nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319723((R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 47nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCell division control protein 42 homolog(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 54nMAssay Description:Inhibition of CDC42More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319722((R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)...)
Affinity DataIC50: 67nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319718(2-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 120nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319724(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-p...)
Affinity DataIC50: 230nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319725(N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-3-p...)
Affinity DataIC50: 240nMAssay Description:Inhibition of ROCK2 by luciferase based ATP detection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50319716((3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PRKCEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed