Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50039164
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50314762(US8629154, 1.2(3) | 5-methyl-2-(methylthio)-3-(phe...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318625(N-Methyl-(3-phenylsulfonyl)-7,8-dihydro-6H-cyclope...)
Affinity DataKi:  0.0880nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318626(N-Methyl-(3-phenylsulfonyl)-6,7,8,9-tetrahydropyra...)
Affinity DataKi:  0.112nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318627(N,5-Dimethyl-3-(phenylsulfonyl)-7,8-dihydro-6H-cyc...)
Affinity DataKi:  0.202nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318633(SB-742457 | 3-benzenesulfonyl-8-piperazin-1-ylquin...)
Affinity DataKi:  0.234nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318624(N,9-Dimethyl-3-(phenylsulfonyl)-5,6,7,8-tetrahydro...)
Affinity DataKi:  0.256nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318626(N-Methyl-(3-phenylsulfonyl)-6,7,8,9-tetrahydropyra...)
Affinity DataKi:  0.259nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318625(N-Methyl-(3-phenylsulfonyl)-7,8-dihydro-6H-cyclope...)
Affinity DataKi:  0.375nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318627(N,5-Dimethyl-3-(phenylsulfonyl)-7,8-dihydro-6H-cyc...)
Affinity DataKi:  0.413nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318628(N,5-Dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydro...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318623(N-Methyl-3-(phenylsulfonyl)-5,6,7,8-tetrahydropyra...)
Affinity DataKi:  0.499nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318623(N-Methyl-3-(phenylsulfonyl)-5,6,7,8-tetrahydropyra...)
Affinity DataKi:  0.542nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318634(N-methyl-3-(phenylsulfonyl)-8-(piperazin-1-yl)-6,7...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to 5HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318630(N,N,5-Trimethyl-3-(phenylsulfonyl)-7,8-dihydro-6H-...)
Affinity DataKi:  25.5nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318629(N,N-Dimethyl-3-(phenylsulfonyl)-7,8-dihydro-6H-cyc...)
Affinity DataKi:  28.8nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318626(N-Methyl-(3-phenylsulfonyl)-6,7,8,9-tetrahydropyra...)
Affinity DataKi:  153nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318623(N-Methyl-3-(phenylsulfonyl)-5,6,7,8-tetrahydropyra...)
Affinity DataKi:  169nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318627(N,5-Dimethyl-3-(phenylsulfonyl)-7,8-dihydro-6H-cyc...)
Affinity DataKi:  188nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318625(N-Methyl-(3-phenylsulfonyl)-7,8-dihydro-6H-cyclope...)
Affinity DataKi:  464nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318631(5-Methyl-3-(phenylsulfonyl)-2-piperazin-1-yl-7,8-d...)
Affinity DataKi:  869nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50318632(5-Methyl-3-(phenylsulfonyl)-2-piperazin-1-yl-6,7,8...)
Affinity DataKi:  1.76E+3nMAssay Description:Antagonist activity at human 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed