Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50041825
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416401(CHEMBL1210640)
Affinity DataEC50:  31.6nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374402(PNU-120596 | CHEMBL257591)
Affinity DataEC50:  158nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416397(CHEMBL1210515)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416408(CHEMBL1210516)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416407(CHEMBL1210517)
Affinity DataEC50:  3.16nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416406(CHEMBL1210518)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416405(CHEMBL1210576)
Affinity DataEC50:  6.31nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416404(CHEMBL1210577)
Affinity DataEC50:  7.94nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416403(CHEMBL1210578)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416402(CHEMBL1210579)
Affinity DataEC50:  10nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416400(CHEMBL1210641)
Affinity DataEC50:  25.1nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416399(CHEMBL1210642)
Affinity DataEC50:  25.1nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416398(CHEMBL1210643)
Affinity DataEC50:  25.1nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416396(CHEMBL1210703)
Affinity DataEC50:  158nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416409(CHEMBL1210702)
Affinity DataEC50:  1.26E+3nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416410(CHEMBL1210458)
Affinity DataEC50:  1.26E+3nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416397(CHEMBL1210515)
Affinity DataIC50: 794nMAssay Description:Antagonist activity at human alpha1 nAChR in human TE671 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416396(CHEMBL1210703)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416396(CHEMBL1210703)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human alpha4 nAChR in human IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416397(CHEMBL1210515)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human alpha3 nAChR in human IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416396(CHEMBL1210703)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human alpha1 nAChR in human TE671 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416396(CHEMBL1210703)
Affinity DataIC50: 2.51E+3nMAssay Description:Antagonist activity at human alpha3 nAChR in human IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416397(CHEMBL1210515)
Affinity DataIC50: 7.94E+3nMAssay Description:Antagonist activity at human 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed