Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50004408
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50109110((S)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbam...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: 3.27E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbam...)
Affinity DataIC50: 3.42E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbam...)
Affinity DataIC50: 3.78E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164({6-Fluoro-2-methyl-3-[1-(4-methylsulfanyl-phenyl)-...)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164({6-Fluoro-2-methyl-3-[1-(4-methylsulfanyl-phenyl)-...)
Affinity DataIC50: 8.25E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50109109((R)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbam...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50109110((S)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbam...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50109110((S)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbam...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164({6-Fluoro-2-methyl-3-[1-(4-methylsulfanyl-phenyl)-...)
Affinity DataIC50: 2.15E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed