Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50032148
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324926((S)-3-(2-Amino-5-chloro-benzoimidazol-1-yl)-pentan...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324903(4-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-cycloh...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324922((3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-(...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324934((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324913(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(c...)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324915((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 7.20E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324931((R)-methyl 2-((S)-3-(2-amino-5-chloro-1H-benzo[d]i...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324908(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(c...)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324932((S)-2-((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol...)
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324927((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324930((S)-methyl 2-((S)-3-(2-amino-5-chloro-1H-benzo[d]i...)
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324904(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-is...)
Affinity DataIC50: 1.93E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324912(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(3...)
Affinity DataIC50: 1.94E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324933((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 2.35E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324920((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 2.43E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324917((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 2.46E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324910(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(3...)
Affinity DataIC50: 2.49E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324929((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 2.64E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324921((3S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)...)
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324909(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(1...)
Affinity DataIC50: 3.25E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324928((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324923((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 3.75E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324907(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(p...)
Affinity DataIC50: 4.26E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324919((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 4.40E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324906(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(2...)
Affinity DataIC50: 4.44E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324914((R)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 5.16E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324918((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 6.95E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM31794(CHEMBL269158 | 6-chloro-1H-benzo[d]imidazol-2-amin...)
Affinity DataIC50: 7.31E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324898(3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)propa...)
Affinity DataIC50: 7.70E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324901(2,2-dihydroxy-1H-indene-1,3(2H)-dione | CHEMBL1221...)
Affinity DataIC50: 7.76E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324905(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(2...)
Affinity DataIC50: 8.27E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324899(3-(3-chlorophenyl)imidazo[1,2-a]pyrimidine | CHEMB...)
Affinity DataIC50: 8.62E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324897(1-methoxy-2-phenyl-1H-imidazo[4,5-b]pyridine | CHE...)
Affinity DataIC50: 9.28E+5nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324911(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(c...)
Affinity DataIC50: 2.85E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324916((R)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324900(3-(pyridin-4-yl)imidazo[1,2-a]pyrimidine | CHEMBL1...)
Affinity DataIC50: 1.01E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324924((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324925((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM50324902(4-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-be...)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of BACE1 assessed as amyloid beta secretion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Evotec

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  8nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  84nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed