Compile Data Set for Download or QSAR
Report error Found 157 Enz. Inhib. hit(s) with all data for entry = 50032364
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327872((1-Butylpiperidin-4-yl)methyl 4-Amino-2-methoxyben...)
Affinity DataEC50:  0.178nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327858(CHEMBL114112 | SB207710 | 8-Amino-7-iodo-2,3-dihyd...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327865((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...)
Affinity DataKi:  0.215nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  0.334nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327864((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...)
Affinity DataKi:  0.334nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327859((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  0.577nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327861((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Affinity DataKi:  0.738nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327862((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Affinity DataKi:  0.901nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327866((1-butylpiperidin-4-yl)methyl 8-amino-2,3-dihydrob...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327858(CHEMBL114112 | SB207710 | 8-Amino-7-iodo-2,3-dihyd...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327861((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327869((1-Butylpiperidin-4-yl)methyl 7-bromo-8-(methylami...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327868((1-Butylpiperidin-4-yl)methyl 8-amino-7-methyl-2,3...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327870((1-Butylpiperidin-4-yl)methyl 7-iodo-8-(methylamin...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327875((1-Butylpiperidin-4-yl)methyl 8-Amino-7-nitro-2,3-...)
Affinity DataKi:  7.80nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327867((1-Butylpiperidin-4-yl)methyl 8-(methylamino)-2,3-...)
Affinity DataEC50:  8.90nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327867((1-Butylpiperidin-4-yl)methyl 8-(methylamino)-2,3-...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327869((1-Butylpiperidin-4-yl)methyl 7-bromo-8-(methylami...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327865((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327874((1-Pentylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327858(CHEMBL114112 | SB207710 | 8-Amino-7-iodo-2,3-dihyd...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327871((1-Butylpiperidin-4-yl)methyl 7-cyano-8-(methylami...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327862((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327864((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327870((1-Butylpiperidin-4-yl)methyl 7-iodo-8-(methylamin...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327859((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327871((1-Butylpiperidin-4-yl)methyl 7-cyano-8-(methylami...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  43nMAssay Description:Binding affinity to rat dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327872((1-Butylpiperidin-4-yl)methyl 4-Amino-2-methoxyben...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  55nMAssay Description:Binding affinity to rat sigma 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  60nMAssay Description:Binding affinity to rat sigma 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  66nMAssay Description:Binding affinity to human 5-HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  88nMAssay Description:Binding affinity to human adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  168nMAssay Description:Binding affinity to human 5-HT2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327861((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Affinity DataKi:  211nMAssay Description:Binding affinity to rat sigma 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  220nMAssay Description:Binding affinity to rat dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  300nMAssay Description:Binding affinity to human 5-HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  316nMAssay Description:Binding affinity to rat dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  336nMAssay Description:Binding affinity to rat dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  433nMAssay Description:Binding affinity to human muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  489nMAssay Description:Binding affinity to human 5-HT6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  522nMAssay Description:Binding affinity to human adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  556nMAssay Description:Binding affinity to human adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  593nMAssay Description:Binding affinity to human adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  615nMAssay Description:Binding affinity to rat dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
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