Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50032365
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50417031(WAY-855 | CHEMBL2062159)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327877((1R*,2R*,3S*,4R*,6R*)-2-Amino-6-phenethyl-bicyclo[...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50004899(L-CCG-IV | 2-(Amino-carboxy-methyl)-cyclopropaneca...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50093753(DL-TBOA | (2S,3S)-2-amino-3-(benzyloxy)succinic ac...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327880((1R*,2R*,3S*,4R*,6R*)-2-Amino-6-butyl-bicyclo[2.2....)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327882((1R*,2R*,3S*,4R*,6R*)-2-Amino-6-[2-(4-chloro-pheny...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327878((1S*,2S*,3R*,4S*,5S*)-2-Amino-5-phenethyl-bicyclo[...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327881((1R*,2R*,3S*,4R*,6R*)-2-Amino-6-[2-(2-hydroxy-phen...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327879((1R*,2R*,3S*,4R*,6R*)-2-Amino-6-propyl-bicyclo[2.2...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50417031(WAY-855 | CHEMBL2062159)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327876((1R*,2R*,3S*,4R*,6S*)-2-Amino-6-vinyl-bicyclo-[2.2...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327886(CHEMBL1256243 | Anti-endo-MPDC | (1R,2S,5S,6S)-3-a...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50197105((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50327885((2S,3S)-pyrrolidine-2,3-dicarboxylic acid | CHEMBL...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
University of Berne

Curated by ChEMBL
LigandPNGBDBM50180145((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed