Compile Data Set for Download or QSAR
Report error Found 110 Enz. Inhib. hit(s) with all data for entry = 50032442
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329313((S)-3-(3-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329309((R)-3-(3-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329313((S)-3-(3-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329312((R)-3-(6-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329314((S)-3-(5-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329311((R)-3-(5-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329309((R)-3-(3-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329312((R)-3-(6-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329318((S)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329306((R)-3-(2-Trifluoromethyl-pyrimidin-4-ylamino)-pyrr...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329292((R)-3-Isobutoxycarbonylamino-pyrrolidine-1-carboxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329317((S)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329314((S)-3-(5-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329288((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329295((R)-3-(tert-Butoxycarbonyl-methyl-amino)-pyrrolidi...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329310((R)-3-(4-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329316((R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329302((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329297((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329303((S)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329311((R)-3-(5-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 5nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329287(Piperidine-1-carboxylic acid adamantan-2-yl ester ...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329318((S)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329305((R)-3-(4-Trifluoromethyl-pyrimidin-2-ylamino)-pyrr...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329291((R)-3-Propoxycarbonylamino-pyrrolidine-1-carboxyli...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329300((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329290((R)-3-Isopropoxycarbonylamino-pyrrolidine-1-carbox...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329306((R)-3-(2-Trifluoromethyl-pyrimidin-4-ylamino)-pyrr...)
Affinity DataIC50: 7nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329304((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329302((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329317((S)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329293((R)-3-Benzyloxycarbonylamino-pyrrolidine-1-carboxy...)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329289((R)-3-Ethoxycarbonylamino-pyrrolidine-1-carboxylic...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329310((R)-3-(4-Trifluoromethyl-pyridin-2-ylamino)-pyrrol...)
Affinity DataIC50: 14.7nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329288((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 15.2nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329296((R)-3-(Benzyl-tert-butoxycarbonyl-amino)-pyrrolidi...)
Affinity DataIC50: 15.3nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329297((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 15.7nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329298((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 15.7nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306409(Piperidine-1-carboxylic acid adamantan-2-ylamide |...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329305((R)-3-(4-Trifluoromethyl-pyrimidin-2-ylamino)-pyrr...)
Affinity DataIC50: 16.4nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329303((S)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 17.6nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329292((R)-3-Isobutoxycarbonylamino-pyrrolidine-1-carboxy...)
Affinity DataIC50: 19.2nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329307((R)-3-(2,6-Dimethyl-pyrimidin-4-ylamino)-pyrrolidi...)
Affinity DataIC50: 20.7nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329308((R)-3-(5-Trifluoromethyl-[1,3,4]thiadiazol-2-ylami...)
Affinity DataIC50: 21.3nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329304((R)-3-tert-Butoxycarbonylamino-pyrrolidine-1-carbo...)
Affinity DataIC50: 24.1nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
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